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- W2080321696 abstract "Indirect effects play a major role in the protection afforded by a vaccination programme. In this work we define new measures of direct, indirect and total (direct + indirect) effects of a vaccination programme in terms of the protection they provide to unvaccinated and vaccinated individuals, and to the entire population. We show how these measures can be estimated using data from a vaccine trial or an observational study. The bias and standard errors of these estimates can be evaluated via stochastic simulations. Examples from a mumps outbreak and a (hypothetical) HIV vaccine trial are used to illustrate the estimation of these new measures of vaccination effectiveness." @default.
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- W2080321696 date "1999-08-30" @default.
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- W2080321696 title "Estimation of the direct and indirect effects of vaccination" @default.
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- W2080321696 doi "https://doi.org/10.1002/(sici)1097-0258(19990830)18:16<2101::aid-sim178>3.0.co;2-6" @default.
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