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- W2080321999 abstract "Activation ofmalEpandmalKp, two divergent promoters fromEscherichia coli, depends on the synergistic action of MalT and CRP. The reaction involves a common regulatory region located in between and comprising multiple binding elements for both regulatory proteins. The binding of MalT and CRP to this region is known to result in the formation of a higher-order structure that is responsible formalKpactivation. This paper presents genetic data which together with previous results, provide compelling evidence that this higher-order structure is also responsible formalEpactivation. The role(s) that this structure or elements thereof play in the activation ofmalEpis analysed by monitoring both the occupancy of the proximal MalT sites (sites 1 and 2) and the activity of differentmalEpvariants in strains containing increasing amounts of active MalT. A truncatedmalEppromoter comprising only MalT sites 1 and 2 forms a minimal MalT-dependent promoter whose activity is limited by the occupancy of these sites. One role of the higher-order structure formed by MalT and CRP when bound to the entire regulatory region is to ensure high occupation of MalT sites 1 and 2, but it is not its only function. Some elements of this structure, namely the CRP site 1, located at −76.5, and the distal MalT sites, seem to play a direct role inmalEpactivation besides their participation in the assembly of the higher-order structure." @default.
- W2080321999 created "2016-06-24" @default.
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- W2080321999 date "1996-12-01" @default.
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- W2080321999 title "On the Role of the Multiple Regulatory Elements Involved in the Activation of theEscherichia coli malEpPromoter" @default.
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- W2080321999 doi "https://doi.org/10.1006/jmbi.1996.0682" @default.
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