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- W2080322455 abstract "Abstract 1. 1. Evidence has been brought foward to indicate that AICA or its riboside are much less efficiently utilised than adenine for DNA and RNA purine synthesis in bone marrow cells in vitro. 2. 2. These experiments again illustrate the necessity of investigation at the cellular level as opposed to “organ specific activity”. Furthermore they illustrate the use of small cell samples for biochemical investigations; although a comparison of adenine 14C and AICA utilisation would be possible by comparison of specific activities of isolated DNA and RNA purines, such isolation procedures would require far larger cell samples than usually obtainable from human bone marrow punctures." @default.
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- W2080322455 date "1959-03-01" @default.
- W2080322455 modified "2023-10-17" @default.
- W2080322455 title "On the utilization of 5-amino-4-imidazole carboxamide (AICA) for purine synthesis by bone marrow cells in vitro" @default.
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- W2080322455 doi "https://doi.org/10.1016/0014-4827(59)90118-1" @default.
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