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- W2080322682 abstract "Aldosterone is classically associated with the regulation of salt and potassium homeostasis but has also profound effects on acid-base balance. During acidosis, circulating aldosterone levels are increased and the hormone acts in concert with angiotensin II and other factors to stimulate renal acid excretion. Pharmacological blockade of aldosterone action as well as inherited or acquired syndromes of impaired aldosterone release or action impair the renal response to acid loading and cause hyperkalemic renal tubular acidosis. The mineralocorticoid receptor (MR) mediating the genomic effects of aldosterone is expressed in all cells of the distal nephron including all subtypes of intercalated cells. In acid-secretory type A intercalated cells, aldosterone stimulates proton secretion into urine, whereas in non-type A intercalated cells, aldosterone increases the activity of the luminal anion exchanger pendrin stimulating bicarbonate secretion and chloride reabsorption. Aldosterone has also stimulatory effects on proton secretion that may be mediated by a non-genomic pathway. In addition, aldosterone indirectly stimulates renal acid excretion by enhancing sodium reabsorption through the epithelial sodium channel ENaC. Increased sodium reabsorption enhances the lumen-negative transepithelial voltage that facilitates proton secretion by neighboring intercalated cells. This indirect coupling of sodium reabsorption and proton secretion is thought to underlie the fludrocortisone-furosemide test for maximal urinary acidification in patients with suspected distal renal tubular acidosis. In patients with CKD, acidosis-induced aldosterone may contribute to progression of kidney disease. In summary, aldosterone is a powerful regulator of renal acid excretion required for normal acid-base balance." @default.
- W2080322682 created "2016-06-24" @default.
- W2080322682 creator A5021707048 @default.
- W2080322682 date "2014-11-06" @default.
- W2080322682 modified "2023-10-06" @default.
- W2080322682 title "Effect of Mineralocorticoids on Acid-Base Balance" @default.
- W2080322682 cites W1567934730 @default.
- W2080322682 cites W1920439767 @default.
- W2080322682 cites W1963902911 @default.
- W2080322682 cites W1965670028 @default.
- W2080322682 cites W1967007307 @default.
- W2080322682 cites W1976644875 @default.
- W2080322682 cites W1977923848 @default.
- W2080322682 cites W1979069430 @default.
- W2080322682 cites W1979670755 @default.
- W2080322682 cites W1982187499 @default.
- W2080322682 cites W1983286927 @default.
- W2080322682 cites W1984717781 @default.
- W2080322682 cites W1985505616 @default.
- W2080322682 cites W1985858914 @default.
- W2080322682 cites W1988786406 @default.
- W2080322682 cites W1990460736 @default.
- W2080322682 cites W1992962615 @default.
- W2080322682 cites W2000448320 @default.
- W2080322682 cites W2000967798 @default.
- W2080322682 cites W2004501944 @default.
- W2080322682 cites W2007152931 @default.
- W2080322682 cites W2008821347 @default.
- W2080322682 cites W2009521188 @default.
- W2080322682 cites W2013610439 @default.
- W2080322682 cites W2021202601 @default.
- W2080322682 cites W2026567508 @default.
- W2080322682 cites W2026841546 @default.
- W2080322682 cites W2030530251 @default.
- W2080322682 cites W2032872477 @default.
- W2080322682 cites W2036607547 @default.
- W2080322682 cites W2036619231 @default.
- W2080322682 cites W2041526137 @default.
- W2080322682 cites W2043666955 @default.
- W2080322682 cites W2044539436 @default.
- W2080322682 cites W2046317583 @default.
- W2080322682 cites W2051194953 @default.
- W2080322682 cites W2052462629 @default.
- W2080322682 cites W2053964593 @default.
- W2080322682 cites W2055733984 @default.
- W2080322682 cites W2056314392 @default.
- W2080322682 cites W2060786529 @default.
- W2080322682 cites W2062554486 @default.
- W2080322682 cites W2068347291 @default.
- W2080322682 cites W2070958498 @default.
- W2080322682 cites W2071808049 @default.
- W2080322682 cites W2073411380 @default.
- W2080322682 cites W2076758026 @default.
- W2080322682 cites W2078671471 @default.
- W2080322682 cites W2078791856 @default.
- W2080322682 cites W2080557891 @default.
- W2080322682 cites W2081516285 @default.
- W2080322682 cites W2081683208 @default.
- W2080322682 cites W2082819736 @default.
- W2080322682 cites W2086726580 @default.
- W2080322682 cites W2088795187 @default.
- W2080322682 cites W2089407550 @default.
- W2080322682 cites W2092711361 @default.
- W2080322682 cites W2093901402 @default.
- W2080322682 cites W2094941289 @default.
- W2080322682 cites W2097312477 @default.
- W2080322682 cites W2102110513 @default.
- W2080322682 cites W2105265963 @default.
- W2080322682 cites W2106000147 @default.
- W2080322682 cites W2107377415 @default.
- W2080322682 cites W2108629029 @default.
- W2080322682 cites W2108930048 @default.
- W2080322682 cites W2111995467 @default.
- W2080322682 cites W2117376136 @default.
- W2080322682 cites W2117687126 @default.
- W2080322682 cites W2124819816 @default.
- W2080322682 cites W2125704085 @default.
- W2080322682 cites W2128741046 @default.
- W2080322682 cites W2132820464 @default.
- W2080322682 cites W2137161526 @default.
- W2080322682 cites W2138146183 @default.
- W2080322682 cites W2141438558 @default.
- W2080322682 cites W2141445963 @default.
- W2080322682 cites W2142766228 @default.
- W2080322682 cites W2146331933 @default.
- W2080322682 cites W2148242263 @default.
- W2080322682 cites W2154076477 @default.
- W2080322682 cites W2159068917 @default.
- W2080322682 cites W2161833682 @default.
- W2080322682 cites W2164860876 @default.
- W2080322682 cites W2165743932 @default.
- W2080322682 cites W2165835843 @default.
- W2080322682 cites W2172109574 @default.
- W2080322682 cites W2172299168 @default.
- W2080322682 cites W3021696019 @default.
- W2080322682 cites W3023992831 @default.
- W2080322682 doi "https://doi.org/10.1159/000368266" @default.
- W2080322682 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25377117" @default.