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- W208032510 abstract "Abstract Autoimmune regulator (Aire) regulates the transcription of a myriad of self antigens in the thymus, which is important for the process of central tolerance to eliminate autoreactive T cells and to prevent autoimmune pathology. Aire-deficient mice (aire-/-) have previously been shown to develop multi-organ autoimmune disorder. We were interested in investigating the role of Aire for autoreactive CD8+ T cells using aire-/-Ia-/- mice. We found that CD8+ T cells were increased in aire-/-Ia-/- mice as compare with their aire+/+ or heterozygous littermates. Furthermore, aire-/-Ia-/- mice showed significantly lower body weight as compared with their littermates. Immune infiltrates mainly composed of CD11c+ cells and CD8+ T cells were found in various tissues of aire-/-Ia-/- mice, especially in liver, lung, pancreas and stomach. Autoantibody was detected in the serum of aire-/-Ia-/- mice directed against gastric tissue and was determined to be predominantly IgM. Collectively, our study shows that autoreactive CD8+ T cells arise on the background of Aire-deficiency are capable of initiating and promoting autoimmunity in the absence of CD4+ T cells." @default.
- W208032510 created "2016-06-24" @default.
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- W208032510 date "2011-04-01" @default.
- W208032510 modified "2023-09-25" @default.
- W208032510 title "Development of autoreactive CD8+ T cells in Aire-deficient mice (101.38)" @default.
- W208032510 doi "https://doi.org/10.4049/jimmunol.186.supp.101.38" @default.
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