FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080327269> ?p ?o ?g. }

• W2080327269 abstract "Staphylococcal enterotoxin B (SEB) and toxic shock syndrome toxin-1 are the super antigens responsible for diseases such as staphylococcal food poisoning and toxic shock syndrome. At low serum concentrations, SEB can trigger toxic shock, profound hypotension and multi organ failure and hence is recognized as biowarfare molecule. In this study, a multidomain fusion protein (r-TE) was generated with specificity for SEB and toxic shock syndrome toxin (Tsst-1). The fusion gene comprising the conserved regions of seb and the tsst genes was codon-optimized for expression in Escherichia coli and encoded a 26 kDa recombinant multidomain chimeric protein (r-TE). Hyperimmune antiserum raised against r-TE specifically reacted with SEB (~28 kDa) and Tsst-1 (~22 kDa) components during Western blot analysis and by plate ELISA in confirmed toxin producing strains of S. aureus. The antigenicity of the SEB component of the r-TE protein was also confirmed using TECRA kit. The described procedure of creating a single protein molecule carrying components of two different toxins whilst still retaining the original antigenic determinants of individual toxins proved highly advantageous in the development of rapid, reliable and cost effective immunoassays and may also have the potential to serve as candidate molecule for vaccine studies." @default.
• W2080327269 created "2016-06-24" @default.
• W2080327269 creator A5021283438 @default.
• W2080327269 creator A5025520167 @default.
• W2080327269 creator A5032980380 @default.
• W2080327269 creator A5049433089 @default.
• W2080327269 creator A5057517536 @default.
• W2080327269 date "2012-03-31" @default.
• W2080327269 modified "2023-09-23" @default.
• W2080327269 title "Application of a Chimeric Protein Construct having Enterotoxin B and Toxic Shock Syndrome Toxin Domains of S. aureus in Immunodiagnostics" @default.
• W2080327269 cites W2008147604 @default.
• W2080327269 cites W2009186025 @default.
• W2080327269 cites W2064769029 @default.
• W2080327269 cites W2068044231 @default.
• W2080327269 cites W2084855813 @default.
• W2080327269 cites W2087466898 @default.
• W2080327269 cites W2097785363 @default.
• W2080327269 cites W2102419473 @default.
• W2080327269 cites W2165952228 @default.
• W2080327269 cites W2166124991 @default.
• W2080327269 cites W2290716284 @default.
• W2080327269 cites W4239096973 @default.
• W2080327269 doi "https://doi.org/10.1007/s12088-012-0269-8" @default.
• W2080327269 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3460130" @default.
• W2080327269 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23997338" @default.
• W2080327269 hasPublicationYear "2012" @default.
• W2080327269 type Work @default.
• W2080327269 sameAs 2080327269 @default.
• W2080327269 citedByCount "4" @default.
• W2080327269 countsByYear W20803272692014 @default.
• W2080327269 countsByYear W20803272692016 @default.
• W2080327269 countsByYear W20803272692021 @default.
• W2080327269 crossrefType "journal-article" @default.
• W2080327269 hasAuthorship W2080327269A5021283438 @default.
• W2080327269 hasAuthorship W2080327269A5025520167 @default.
• W2080327269 hasAuthorship W2080327269A5032980380 @default.
• W2080327269 hasAuthorship W2080327269A5049433089 @default.
• W2080327269 hasAuthorship W2080327269A5057517536 @default.
• W2080327269 hasBestOaLocation W20803272692 @default.
• W2080327269 hasConcept C104317684 @default.
• W2080327269 hasConcept C123894998 @default.
• W2080327269 hasConcept C147483822 @default.
• W2080327269 hasConcept C153911025 @default.
• W2080327269 hasConcept C159047783 @default.
• W2080327269 hasConcept C203014093 @default.
• W2080327269 hasConcept C2777367657 @default.
• W2080327269 hasConcept C2779026604 @default.
• W2080327269 hasConcept C2779489039 @default.
• W2080327269 hasConcept C2779821349 @default.
• W2080327269 hasConcept C36333154 @default.
• W2080327269 hasConcept C40767141 @default.
• W2080327269 hasConcept C523546767 @default.
• W2080327269 hasConcept C54355233 @default.
• W2080327269 hasConcept C547475151 @default.
• W2080327269 hasConcept C55493867 @default.
• W2080327269 hasConcept C66999527 @default.
• W2080327269 hasConcept C86803240 @default.
• W2080327269 hasConcept C89423630 @default.
• W2080327269 hasConcept C91523082 @default.
• W2080327269 hasConceptScore W2080327269C104317684 @default.
• W2080327269 hasConceptScore W2080327269C123894998 @default.
• W2080327269 hasConceptScore W2080327269C147483822 @default.
• W2080327269 hasConceptScore W2080327269C153911025 @default.
• W2080327269 hasConceptScore W2080327269C159047783 @default.
• W2080327269 hasConceptScore W2080327269C203014093 @default.
• W2080327269 hasConceptScore W2080327269C2777367657 @default.
• W2080327269 hasConceptScore W2080327269C2779026604 @default.
• W2080327269 hasConceptScore W2080327269C2779489039 @default.
• W2080327269 hasConceptScore W2080327269C2779821349 @default.
• W2080327269 hasConceptScore W2080327269C36333154 @default.
• W2080327269 hasConceptScore W2080327269C40767141 @default.
• W2080327269 hasConceptScore W2080327269C523546767 @default.
• W2080327269 hasConceptScore W2080327269C54355233 @default.
• W2080327269 hasConceptScore W2080327269C547475151 @default.
• W2080327269 hasConceptScore W2080327269C55493867 @default.
• W2080327269 hasConceptScore W2080327269C66999527 @default.
• W2080327269 hasConceptScore W2080327269C86803240 @default.
• W2080327269 hasConceptScore W2080327269C89423630 @default.
• W2080327269 hasConceptScore W2080327269C91523082 @default.
• W2080327269 hasLocation W20803272691 @default.
• W2080327269 hasLocation W20803272692 @default.
• W2080327269 hasLocation W20803272693 @default.
• W2080327269 hasLocation W20803272694 @default.
• W2080327269 hasOpenAccess W2080327269 @default.
• W2080327269 hasPrimaryLocation W20803272691 @default.
• W2080327269 hasRelatedWork W1551455499 @default.
• W2080327269 hasRelatedWork W1963923597 @default.
• W2080327269 hasRelatedWork W1965726695 @default.
• W2080327269 hasRelatedWork W1971139113 @default.
• W2080327269 hasRelatedWork W2003152499 @default.
• W2080327269 hasRelatedWork W2073810303 @default.
• W2080327269 hasRelatedWork W2079329109 @default.
• W2080327269 hasRelatedWork W2124677962 @default.
• W2080327269 hasRelatedWork W2161739915 @default.
• W2080327269 hasRelatedWork W2286929888 @default.
• W2080327269 hasRelatedWork W2337236262 @default.
• W2080327269 hasRelatedWork W2460485777 @default.
• W2080327269 hasRelatedWork W2529353890 @default.
• W2080327269 hasRelatedWork W2587908093 @default.
• W2080327269 hasRelatedWork W298880985 @default.

• next