FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080328193> ?p ?o ?g. }

• W2080328193 endingPage "94" @default.
• W2080328193 startingPage "85" @default.
• W2080328193 abstract "Induction of apoptosis and changes to cytokine secretion patterns have been implicated in the mechanism of action of extracorporeal photopheresis (ECP). Lymphocyte apoptosis is initially detected in significant numbers prior to re-infusion and by 48 h post-ECP the majority of treated lymphocytes are apoptotic. The early apoptosis involves changes to mitochondrial function, reversal of the Bcl-2/Bax ratio and externalisation of phosphatidylserine. Apoptotic lymphocytes, observed from 20 h post-ECP, are associated with enhanced levels of CD95 and Fas-ligand. For cutaneous T cell lymphoma (CTCL), processing of the apoptotic lymphocytes, by suitable antigen presenting cells (APCs), is suggested to induce a clonal cytotoxic response which targets the malignant T cell population. Increased levels of TNFalpha and IFNgamma, observed post-ECP in monocytes and lymphocytes, respectively, are thought to further contribute to the proposed anti-tumour reaction seen in CTCL. However, down-regulation of pro-inflammatory cytokines and enhanced anti-inflammatory responses have been reported following ECP treatment. These immune responses may contribute to the tempering of the inflammatory conditions, such as graft versus host disease, which respond to ECP. Furthermore, untreated monocytes exposed to ECP-treated lymphocytes have also demonstrated a shift in monocyte cytokine-secretory pattern, toward one associated with immune tolerance. Recently, a mechanism of ECP-induced immune tolerance has been linked to the stimulation of the anti-inflammatory cytokines IL10 and TGFbeta by T regulatory cells, following the infusion of ECP-treated CD11c(+) APCs. Ultimately, the multifaceted responses, induced by ECP, may explain the diversity of clinical conditions that benefit." @default.
• W2080328193 created "2016-06-24" @default.
• W2080328193 creator A5049261212 @default.
• W2080328193 creator A5075668451 @default.
• W2080328193 date "2006-08-01" @default.
• W2080328193 modified "2023-10-18" @default.
• W2080328193 title "Extracorporeal photopheresis: A focus on apoptosis and cytokines" @default.
• W2080328193 cites W1561123810 @default.
• W2080328193 cites W1573103899 @default.
• W2080328193 cites W1589415602 @default.
• W2080328193 cites W1598996496 @default.
• W2080328193 cites W1675113161 @default.
• W2080328193 cites W186409735 @default.
• W2080328193 cites W1964109457 @default.
• W2080328193 cites W1966412107 @default.
• W2080328193 cites W1973696041 @default.
• W2080328193 cites W1974710403 @default.
• W2080328193 cites W1975712571 @default.
• W2080328193 cites W1976231672 @default.
• W2080328193 cites W1977090787 @default.
• W2080328193 cites W1986206113 @default.
• W2080328193 cites W1988213681 @default.
• W2080328193 cites W1994764453 @default.
• W2080328193 cites W1995622152 @default.
• W2080328193 cites W1996869817 @default.
• W2080328193 cites W1997208169 @default.
• W2080328193 cites W1999159640 @default.
• W2080328193 cites W2000791674 @default.
• W2080328193 cites W2001842364 @default.
• W2080328193 cites W2008095691 @default.
• W2080328193 cites W2008459543 @default.
• W2080328193 cites W2012182787 @default.
• W2080328193 cites W2022823235 @default.
• W2080328193 cites W2023509911 @default.
• W2080328193 cites W2024594863 @default.
• W2080328193 cites W2025052382 @default.
• W2080328193 cites W2028573751 @default.
• W2080328193 cites W2029117355 @default.
• W2080328193 cites W2030892254 @default.
• W2080328193 cites W2030938503 @default.
• W2080328193 cites W2036424821 @default.
• W2080328193 cites W2040111293 @default.
• W2080328193 cites W2042961427 @default.
• W2080328193 cites W2044158364 @default.
• W2080328193 cites W2046087898 @default.
• W2080328193 cites W2046273895 @default.
• W2080328193 cites W2047021387 @default.
• W2080328193 cites W2050213014 @default.
• W2080328193 cites W2054955905 @default.
• W2080328193 cites W2055796980 @default.
• W2080328193 cites W2056040974 @default.
• W2080328193 cites W2059340815 @default.
• W2080328193 cites W2061497413 @default.
• W2080328193 cites W2066659903 @default.
• W2080328193 cites W2067531412 @default.
• W2080328193 cites W2068585118 @default.
• W2080328193 cites W2077987011 @default.
• W2080328193 cites W2085249569 @default.
• W2080328193 cites W2085704445 @default.
• W2080328193 cites W2088127225 @default.
• W2080328193 cites W2088303434 @default.
• W2080328193 cites W2091822464 @default.
• W2080328193 cites W2111127937 @default.
• W2080328193 cites W2116493118 @default.
• W2080328193 cites W2116616281 @default.
• W2080328193 cites W2117947280 @default.
• W2080328193 cites W2127436608 @default.
• W2080328193 cites W2128303912 @default.
• W2080328193 cites W2135625721 @default.
• W2080328193 cites W2136492223 @default.
• W2080328193 cites W2146331182 @default.
• W2080328193 cites W2152060088 @default.
• W2080328193 cites W2157348405 @default.
• W2080328193 cites W2161503027 @default.
• W2080328193 cites W2162553970 @default.
• W2080328193 cites W2172466148 @default.
• W2080328193 cites W2287087682 @default.
• W2080328193 cites W2328105170 @default.
• W2080328193 cites W2337557724 @default.
• W2080328193 cites W72012428 @default.
• W2080328193 cites W2004590733 @default.
• W2080328193 doi "https://doi.org/10.1016/j.jdermsci.2006.05.004" @default.
• W2080328193 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16797926" @default.
• W2080328193 hasPublicationYear "2006" @default.
• W2080328193 type Work @default.
• W2080328193 sameAs 2080328193 @default.
• W2080328193 citedByCount "80" @default.
• W2080328193 countsByYear W20803281932012 @default.
• W2080328193 countsByYear W20803281932013 @default.
• W2080328193 countsByYear W20803281932014 @default.
• W2080328193 countsByYear W20803281932015 @default.
• W2080328193 countsByYear W20803281932016 @default.
• W2080328193 countsByYear W20803281932017 @default.
• W2080328193 countsByYear W20803281932018 @default.
• W2080328193 countsByYear W20803281932019 @default.
• W2080328193 countsByYear W20803281932020 @default.
• W2080328193 countsByYear W20803281932021 @default.
• W2080328193 countsByYear W20803281932022 @default.

• next