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- W2080329266 abstract "A241 Aims: Sirolimus (SRL) was found to provide effective immunosuppression (IS) in kidney transplantation(Tx) in combination with reduced doses of calcineurin inhibitors (CI), resulting in less CI related toxicity. The aim of this investigation was to reach a stable renal function in the long term follow up after renal transplantation. Methods: 10 pat. (5 female, 5 male) were included after first transplantation. Median age was 45 (27-55) years. Indication for an immunosuppression with lower nephrotoxic potential was an ischemic period of more then 20 hours, an preexcisting diabetes mellitus, preexcisting tumor disease or a donor organ older then 60 years. For immunosuppression were given SRL, Tacrolimus (TAC) and Steroids. In one pat. with panel reactivity of 78% ATG as induction therapy was given. Aimed trough levels for SRL were 6-8 ng/ml, TAC 5-7 ng/ml, Steroids were tapered to 7,5mg daily. After 2 years steroids were stopped and in the following period TAC was withdrawn. Results: The median follow up was 1400 (1366-1413) days. The median serum creatinine was 127μmol/l (range 81-188) 30 days, 133μmol/l (range 81-156) 1year, 131μmol/l (60-176) 2 years and 131μmol/l (70-241) 3 years after Tx. We did not observe a rejection episode (5 biopsies in 5 pat.) and CMV infection. Wound healing was comparable to pat. with other immunosuppression protocols in our center. Blood pressure and glucose metabolism were not influenced by this IS protocol. Increase of serum triglycerides was well under control with lipid lowering medication. 8/10 pat. are on lipid lowering therapy. We did not observe any thrombocytopenia. 3 years after Tx 1 pat. died because of acute myocardial infarction. Conclusion: The primary IS with SRL and TAC seems to be safe and shows a stable renal function more then 3 years after Tx. We observed no viral infection in this pat. An enlarged observation period and/or a prospective study may be of helpfull to confirm these encouraging results." @default.
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- W2080329266 date "2004-07-01" @default.
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- W2080329266 title "3 YEAR FOLLOW UP OF SIROLIMUS BASED IMMUNOSUPPRESSION FOR RENAL ALLOGRAFT RECIPIENTS" @default.
- W2080329266 doi "https://doi.org/10.1097/00007890-200407271-01967" @default.
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