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- W2080334669 abstract "A study on the central effects of four methoxy-substituted amphetamines, of myristicin, and of macromerine has been carried out using rats, rabbits, and cats bearing chronically implanted electrodes. In the rat and in the rabbit the amphetamine derivatives gave rise to a syndrome consisting of a mixture of depression and excitation. Activation of the EEG occurred after small doses of all the drugs, while high doses induced the appearance of spikes and, in some instances, of a grand mal seizure. In the rat, neurovegetative disturbances (vasodilatation) and ejaculation were observed with some of the compounds. Myristicin and macromerine influenced only slightly the EEG and the behavior. The cats, which were trained to an instrumental reward discrimination response, proved to be the most sensitive animal to the effect of these substances. The four amphetamine derivatives, in appropriate dosage, blocked conditioned behavior and caused bizarre behavioral (“hallucinatory”) patterns. The behavioral alterations were independent from the modifications of the EEG. A clear-cut EEG activation has been observed only after DOM, while the other derivatives caused a mixed tracing and, with higher doses, synchronization. The correlation between the central activity of these compounds in the various animal species tested in these experiments and their hallucinogenic properties in man indicate that the conditioned cat is the best suited animal for research in this field, since a good relationship exists between the order of potency in disrupting the conditioned response and the human data." @default.
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- W2080334669 title "EEG and behavioral effects in animals of some amphetamine derivatives with hallucinogenic properties" @default.
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- W2080334669 doi "https://doi.org/10.1016/s0091-6773(72)80112-3" @default.
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