FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080335349> ?p ?o ?g. }

• W2080335349 endingPage "265" @default.
• W2080335349 startingPage "254" @default.
• W2080335349 abstract "Triplex structure-forming GAA/TTC repeats pose a dual threat to the eukaryotic genome integrity. Their potential to expand can lead to gene inactivation, the cause of Friedreich’s ataxia disease in humans. In model systems, long GAA/TTC tracts also act as chromosomal fragile sites that can trigger gross chromosomal rearrangements. The mechanisms that regulate the metabolism of GAA/TTC repeats are poorly understood. We have developed an experimental system in the yeast Saccharomyces cerevisiae that allows us to systematically identify genes crucial for maintaining the repeat stability. Two major groups of mutants defective in DNA replication or transcription initiation are found to be prone to fragility and large-scale expansions. We demonstrate that problems imposed by the repeats during DNA replication in actively dividing cells and during transcription initiation in nondividing cells can culminate in genome instability. We propose that similar mechanisms can mediate detrimental metabolism of GAA/TTC tracts in human cells." @default.
• W2080335349 created "2016-06-24" @default.
• W2080335349 creator A5030237153 @default.
• W2080335349 creator A5035961413 @default.
• W2080335349 creator A5038374223 @default.
• W2080335349 creator A5042221842 @default.
• W2080335349 creator A5043652939 @default.
• W2080335349 creator A5045487840 @default.
• W2080335349 creator A5050230143 @default.
• W2080335349 creator A5063124326 @default.
• W2080335349 date "2012-10-01" @default.
• W2080335349 modified "2023-10-16" @default.
• W2080335349 title "Genome-wide Screen Identifies Pathways that Govern GAA/TTC Repeat Fragility and Expansions in Dividing and Nondividing Yeast Cells" @default.
• W2080335349 cites W1595069818 @default.
• W2080335349 cites W1963604994 @default.
• W2080335349 cites W1965343035 @default.
• W2080335349 cites W1965493201 @default.
• W2080335349 cites W1966624844 @default.
• W2080335349 cites W1967512385 @default.
• W2080335349 cites W1978740993 @default.
• W2080335349 cites W1984708728 @default.
• W2080335349 cites W1994522992 @default.
• W2080335349 cites W1996425563 @default.
• W2080335349 cites W2024374899 @default.
• W2080335349 cites W2026380481 @default.
• W2080335349 cites W2030122482 @default.
• W2080335349 cites W2035301928 @default.
• W2080335349 cites W2037860289 @default.
• W2080335349 cites W2040392790 @default.
• W2080335349 cites W2040976733 @default.
• W2080335349 cites W2044667775 @default.
• W2080335349 cites W2046610007 @default.
• W2080335349 cites W2065779053 @default.
• W2080335349 cites W2065888384 @default.
• W2080335349 cites W2067466498 @default.
• W2080335349 cites W2070650525 @default.
• W2080335349 cites W2079296555 @default.
• W2080335349 cites W2080139629 @default.
• W2080335349 cites W2081433439 @default.
• W2080335349 cites W2087013595 @default.
• W2080335349 cites W2088784554 @default.
• W2080335349 cites W2091578291 @default.
• W2080335349 cites W2094744817 @default.
• W2080335349 cites W2099564858 @default.
• W2080335349 cites W2105564521 @default.
• W2080335349 cites W2111714867 @default.
• W2080335349 cites W2112450680 @default.
• W2080335349 cites W2117348845 @default.
• W2080335349 cites W2123017921 @default.
• W2080335349 cites W2124259570 @default.
• W2080335349 cites W2127073167 @default.
• W2080335349 cites W2130910832 @default.
• W2080335349 cites W2134573093 @default.
• W2080335349 cites W2146797616 @default.
• W2080335349 cites W2153087859 @default.
• W2080335349 cites W2156532481 @default.
• W2080335349 cites W2158155007 @default.
• W2080335349 cites W2162362951 @default.
• W2080335349 cites W2166020754 @default.
• W2080335349 cites W2166353874 @default.
• W2080335349 cites W2168365185 @default.
• W2080335349 cites W2169473513 @default.
• W2080335349 cites W2171820509 @default.
• W2080335349 cites W4232922293 @default.
• W2080335349 doi "https://doi.org/10.1016/j.molcel.2012.08.002" @default.
• W2080335349 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3635072" @default.
• W2080335349 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22959270" @default.
• W2080335349 hasPublicationYear "2012" @default.
• W2080335349 type Work @default.
• W2080335349 sameAs 2080335349 @default.
• W2080335349 citedByCount "57" @default.
• W2080335349 countsByYear W20803353492012 @default.
• W2080335349 countsByYear W20803353492013 @default.
• W2080335349 countsByYear W20803353492014 @default.
• W2080335349 countsByYear W20803353492015 @default.
• W2080335349 countsByYear W20803353492016 @default.
• W2080335349 countsByYear W20803353492017 @default.
• W2080335349 countsByYear W20803353492018 @default.
• W2080335349 countsByYear W20803353492019 @default.
• W2080335349 countsByYear W20803353492020 @default.
• W2080335349 countsByYear W20803353492021 @default.
• W2080335349 countsByYear W20803353492022 @default.
• W2080335349 countsByYear W20803353492023 @default.
• W2080335349 crossrefType "journal-article" @default.
• W2080335349 hasAuthorship W2080335349A5030237153 @default.
• W2080335349 hasAuthorship W2080335349A5035961413 @default.
• W2080335349 hasAuthorship W2080335349A5038374223 @default.
• W2080335349 hasAuthorship W2080335349A5042221842 @default.
• W2080335349 hasAuthorship W2080335349A5043652939 @default.
• W2080335349 hasAuthorship W2080335349A5045487840 @default.
• W2080335349 hasAuthorship W2080335349A5050230143 @default.
• W2080335349 hasAuthorship W2080335349A5063124326 @default.
• W2080335349 hasBestOaLocation W20803353491 @default.
• W2080335349 hasConcept C104317684 @default.
• W2080335349 hasConcept C138885662 @default.
• W2080335349 hasConcept C141231307 @default.
• W2080335349 hasConcept C143425029 @default.
• W2080335349 hasConcept C178169997 @default.

• next