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- W2080335952 endingPage "16" @default.
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- W2080335952 abstract "The periodontium and periodontal disease activity can be affected by systemic drug therapy. Many drugs can have an adverse effect on the periodontium, i.e., gingival hyperplasia. Alternatively, some drugs can modify the inflammatory and immunological responses of the periodontal tissues to bacterial plaque. The aim of this review is to evaluate the effects of drug therapy on the periodontium and periodontal disease activity, and where possible, to relate such changes to the pharmacodynamics of the drugs considered. Drugs which have been reported to affect the periodontium can be categorised as follows: anti-epileptics, immunosuppressants, corticosteroids, non-steroidal anti-inflammatory drugs and hormones. Those drugs whose pharmacodynamics are clearly established and which affect the rate of periodontal disease activity, may provide information on the mechanisms of periodontal destruction. Finally, the mechanisms of drug-induced gingival hyperplasia (overgrowth) are discussed in relationship to the drugs' pharmacodynamics and pharmacokinetics." @default.
- W2080335952 created "2016-06-24" @default.
- W2080335952 creator A5022913673 @default.
- W2080335952 creator A5064928392 @default.
- W2080335952 date "1988-01-01" @default.
- W2080335952 modified "2023-09-25" @default.
- W2080335952 title "Drugs and the periodontium" @default.
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