FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080337402> ?p ?o ?g. }

• W2080337402 endingPage "739" @default.
• W2080337402 startingPage "729" @default.
• W2080337402 abstract "Abstract Marked species differences of dioxin toxicity prompted the review of three well-studied human dioxin toxicities (chloracne, inflammation and cancer) and deregulated Ah receptor (AhR) target genes to obtain hints as to the physiological functions of this receptor. Dioxin here stands for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Microarray analysis of dermal cysts from a dioxin-poisoned patient revealed, in addition to induced CYP1A1, increased expression of gremlin, an antagonist of bone morphogenetic proteins. Dioxin-mediated skin and intestinal inflammation is associated with deregulated T cell differentiation. In the supernatant of CD4 + T cells obtained from the dioxin-poisoned patient, increased interleukin-22 was detected, a cytokine that may be controlled in part by AhR-regulated Notch. Cancer is one of the long-term consequences of chronic inflammation. In line with dioxin-sensitive lymphoid tissue, enhanced death of lymphoid cancer was observed in the dioxin-exposed Seveso population 25 years after poisoning. Accumulating evidence suggests that endogenous AhR ligands, notably the tryptophan photoproduct 6-formylindolo[3,2-b]carbazole, in contrast to TCDD, is rapidly metabolized by AhR-induced CYP1A1. The feedback loop between 6-formylindolo[3,2-b]carbazole, AhR and CYP1A1 guarantees transient activation that, in contrast to sustained activation by TCDD, may be essential for a putative role of the AhR in stem/progenitor cell homeostasis." @default.
• W2080337402 created "2016-06-24" @default.
• W2080337402 creator A5032074919 @default.
• W2080337402 date "2013-01-31" @default.
• W2080337402 modified "2023-10-14" @default.
• W2080337402 title "The human Ah receptor: hints from dioxin toxicities to deregulated target genes and physiological functions" @default.
• W2080337402 cites W1516534743 @default.
• W2080337402 cites W2003557993 @default.
• W2080337402 cites W2015447462 @default.
• W2080337402 cites W2019771038 @default.
• W2080337402 cites W2020792897 @default.
• W2080337402 cites W2020873521 @default.
• W2080337402 cites W2026209468 @default.
• W2080337402 cites W2027384271 @default.
• W2080337402 cites W2033635252 @default.
• W2080337402 cites W2036792438 @default.
• W2080337402 cites W2042534735 @default.
• W2080337402 cites W2044019076 @default.
• W2080337402 cites W2044544228 @default.
• W2080337402 cites W2053082554 @default.
• W2080337402 cites W2065072182 @default.
• W2080337402 cites W2071813734 @default.
• W2080337402 cites W2072222745 @default.
• W2080337402 cites W2076927594 @default.
• W2080337402 cites W2083380982 @default.
• W2080337402 cites W2091974897 @default.
• W2080337402 cites W2094530868 @default.
• W2080337402 cites W2095341699 @default.
• W2080337402 cites W2097615954 @default.
• W2080337402 cites W2097989455 @default.
• W2080337402 cites W2107312924 @default.
• W2080337402 cites W2107459338 @default.
• W2080337402 cites W2115277334 @default.
• W2080337402 cites W2124739658 @default.
• W2080337402 cites W2140551998 @default.
• W2080337402 cites W2146909058 @default.
• W2080337402 cites W2148529156 @default.
• W2080337402 cites W2151131523 @default.
• W2080337402 cites W2155528979 @default.
• W2080337402 cites W2170264506 @default.
• W2080337402 doi "https://doi.org/10.1515/hsz-2012-0340" @default.
• W2080337402 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23370907" @default.
• W2080337402 hasPublicationYear "2013" @default.
• W2080337402 type Work @default.
• W2080337402 sameAs 2080337402 @default.
• W2080337402 citedByCount "37" @default.
• W2080337402 countsByYear W20803374022013 @default.
• W2080337402 countsByYear W20803374022014 @default.
• W2080337402 countsByYear W20803374022015 @default.
• W2080337402 countsByYear W20803374022016 @default.
• W2080337402 countsByYear W20803374022017 @default.
• W2080337402 countsByYear W20803374022018 @default.
• W2080337402 countsByYear W20803374022019 @default.
• W2080337402 countsByYear W20803374022020 @default.
• W2080337402 countsByYear W20803374022021 @default.
• W2080337402 countsByYear W20803374022022 @default.
• W2080337402 crossrefType "journal-article" @default.
• W2080337402 hasAuthorship W2080337402A5032074919 @default.
• W2080337402 hasConcept C104317684 @default.
• W2080337402 hasConcept C126322002 @default.
• W2080337402 hasConcept C134018914 @default.
• W2080337402 hasConcept C170493617 @default.
• W2080337402 hasConcept C185592680 @default.
• W2080337402 hasConcept C203014093 @default.
• W2080337402 hasConcept C2776914184 @default.
• W2080337402 hasConcept C2778690821 @default.
• W2080337402 hasConcept C2908647359 @default.
• W2080337402 hasConcept C33594762 @default.
• W2080337402 hasConcept C502942594 @default.
• W2080337402 hasConcept C55493867 @default.
• W2080337402 hasConcept C71924100 @default.
• W2080337402 hasConcept C86339819 @default.
• W2080337402 hasConcept C86803240 @default.
• W2080337402 hasConcept C95444343 @default.
• W2080337402 hasConcept C99454951 @default.
• W2080337402 hasConceptScore W2080337402C104317684 @default.
• W2080337402 hasConceptScore W2080337402C126322002 @default.
• W2080337402 hasConceptScore W2080337402C134018914 @default.
• W2080337402 hasConceptScore W2080337402C170493617 @default.
• W2080337402 hasConceptScore W2080337402C185592680 @default.
• W2080337402 hasConceptScore W2080337402C203014093 @default.
• W2080337402 hasConceptScore W2080337402C2776914184 @default.
• W2080337402 hasConceptScore W2080337402C2778690821 @default.
• W2080337402 hasConceptScore W2080337402C2908647359 @default.
• W2080337402 hasConceptScore W2080337402C33594762 @default.
• W2080337402 hasConceptScore W2080337402C502942594 @default.
• W2080337402 hasConceptScore W2080337402C55493867 @default.
• W2080337402 hasConceptScore W2080337402C71924100 @default.
• W2080337402 hasConceptScore W2080337402C86339819 @default.
• W2080337402 hasConceptScore W2080337402C86803240 @default.
• W2080337402 hasConceptScore W2080337402C95444343 @default.
• W2080337402 hasConceptScore W2080337402C99454951 @default.
• W2080337402 hasIssue "6" @default.
• W2080337402 hasLocation W20803374021 @default.
• W2080337402 hasLocation W20803374022 @default.
• W2080337402 hasOpenAccess W2080337402 @default.
• W2080337402 hasPrimaryLocation W20803374021 @default.
• W2080337402 hasRelatedWork W1974048771 @default.

• next