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- W2080338746 endingPage "1522" @default.
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- W2080338746 abstract "ObjectivesAccording to the 2007 National Research Council report Toxicology for the Twenty-First Century, modern methods (e.g., “omics,” in vitro assays, high-throughput testing, computational methods) will lead to the emergence of a new approach to toxicology. The Salmonella mammalian microsome mutagenicity assay has been central to the field of genetic toxicology since the 1970s. Here we document the paradigm shifts engendered by the assay, the validation and applications of the assay, and how the assay is a model for future in vitro toxicology assays.Data sourcesWe searched PubMed, Scopus, and Web of Knowledge using key words relevant to the Salmonella assay and additional genotoxicity assays.Data extractionWe merged the citations, removing duplicates, and categorized the papers by year and topic.Data synthesisThe Salmonella assay led to two paradigm shifts: that some carcinogens were mutagens and that some environmental samples (e.g., air, water, soil, food, combustion emissions) were mutagenic. Although there are > 10,000 publications on the Salmonella assay, covering tens of thousands of agents, data on even more agents probably exist in unpublished form, largely as proprietary studies by industry. The Salmonella assay is a model for the development of 21st century in vitro toxicology assays in terms of the establishment of standard procedures, ability to test various agents, transferability across laboratories, validation and testing, and structure–activity analysis.ConclusionsSimilar to a stethoscope as a first-line, inexpensive tool in medicine, the Salmonella assay can serve a similar, indispensable role in the foreseeable future of 21st century toxicology." @default.
- W2080338746 created "2016-06-24" @default.
- W2080338746 creator A5035667778 @default.
- W2080338746 creator A5079881408 @default.
- W2080338746 creator A5091863262 @default.
- W2080338746 date "2010-11-01" @default.
- W2080338746 modified "2023-10-16" @default.
- W2080338746 title "The <i>Salmonella</i> Mutagenicity Assay: The Stethoscope of Genetic Toxicology for the 21st Century" @default.
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