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- W2080341461 abstract "Heteroduplex DNA of bacteriophage f1 constructed in vitro was used to transfect Escherichia coli. The progeny phage produced were analyzed by genetic means. A strongly asymmetric transfer of information was observed. This result shows that one strand—usually the minus strand—determines in large part the genotypes of progeny phage. These results are discussed in the light of the available information on DNA duplication. Evidence for an activity that corrects mismatched bases will be presented and discussed. Heteroduplex molecules which were heterozygous at the sites that govern sensitivity to B restriction and modification were constructed and analyzed in restricting and non-restricting hosts. Results of these studies give support to a model for f1 genetic recombination that envisages asymmetric heteroduplex formation as an intermediate. These results are discussed in relation to earlier data." @default.
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- W2080341461 date "1975-08-01" @default.
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- W2080341461 title "Genetic studies with heteroduplex DNA of bacteriophage f1. Asymmetric segregation, base correction and implications for the mechanism of genetic recombination" @default.
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- W2080341461 doi "https://doi.org/10.1016/0022-2836(75)90175-8" @default.
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