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- W2080344568 abstract "Cytotoxic T cells specific for influenza viras A/HK or Epstein-Barr virus were used to study the heterogeneity of the HLA-A3 molecule. Variability of the recognition of HLA-A3 in both systems was observed. The hierarchy was both effector cell and target cell specific. An extreme example of the hierarchy of HLA-A3 recognition is the following. Virus-specific cytotoxic T lymphocytes of a given donor were found to recognize all HLA-A3-matched target cells, including target cells of a donor from whom the virus-specific effector cells did not recognize target cells of that given donor: Donor A recognizes target B but donor B does not recognize target A. Both will recognize a third HLA-A3-matched target cell C. Cold target inhibition studies confirmed that the recognition of target cell B by effector cell A involved the recognition of only HLA-A3. Examples of such asymmetric recognition were found in both influenza A and Epstein-Barr virus-specific cytotoxic T-lymphocyte responses but not one combination was asymmetric in both systems. This suggests that influenza virus A/HK-specific cytotoxic T lymphocytes recognize other HLA-A3 histotopes than do Epstein-Barr virus-specific cytotoxic T lymphocytes." @default.
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- W2080344568 date "1985-07-01" @default.
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- W2080344568 title "Asymmetry in the recognition of HLA-A3 molecules by virus-specific cytotoxic T cells" @default.
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- W2080344568 doi "https://doi.org/10.1016/0008-8749(85)90154-6" @default.
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