FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080348770> ?p ?o ?g. }

• W2080348770 endingPage "335" @default.
• W2080348770 startingPage "332" @default.
• W2080348770 abstract "The skill of the diagnostic radiologist in manipulating a percutaneous arterial catheter might be applied to clinical radiation therapy in a technic currently under investigation. A dose of 2,300 rads is the practical limit for radiation fields encompassing both kidneys; higher amounts lead to delayed radiation nephritis in a significant proportion of cases (1, 6). It is thought that catheterization of the renal artery with infusion of a radioprotective agent during therapy might provide protection to the kidney against radiation damage. In this way, a much higher radiation dose could be delivered to overlying tumor tissue without the risk of late radiation nephritis. Several methods have been used clinically to create or to enhance a difference in radiation sensitivity between tumor and normal tissues. Tissue oxygenation is the single most important (and the most easily altered) factor in determining local tissue radiosensitivity (2, 4). Attempts have been made to employ hyperbaric oxygen to effect a more favorable ratio between tumor and normal tissue sensitivities (3, 4). Arterial infusions of hydrogen peroxide have also been tried in an effort to raise oxygen tension locally and to increase sensitivity of tumor tissue to radiation (7). We have taken a different approach. Experimentally, we have succeeded in protecting a critical (dose-limiting) organ in radiation therapy, the normal kidney, by infusing small amounts of epinephrine selectively into the renal artery before and during radiation. Epinephrine-induced vasoconstriction causes a marked decrease in the renal blood flow and temporary renal anoxia, with a striking radioprotective effect on the canine kidney. Methods and Results The studies proceeded in four stages. First (part 1), flow measurements and blood analyses established the ability of renal artery epinephrine infusions to produce renal hypoxia. “Control” studies (part 2) next established the safety of epinephrine infusions at the required dose level and determined the local radiation dose needed to produce severe renal damage in the dog. Following this, the epinephrine infusion technic was applied experimentally to radioprotection of the kidney (part 3). Finally (part 4), a pilot clinical study was initiated, using an indwelling renal artery catheter in a patient with advanced abdominal cancer. Part 1: Physiological Studies (3 dogs)2: The animal was anesthetized with intravenous pentobarbital, the abdomen opened, and a catheter passed via the femoral artery into one renal artery. The corresponding renal vein was then sectioned, and the effluent renal vein blood conducted to a venous reservoir in order to measure its flow. From the reservoir, the blood was immediately reinfused into a femoral vein. Renal vein oxygen saturation, pH, and lactate/pyruvate ratio were also measured during a control period and then during infusion of epinephrine into the renal artery." @default.
• W2080348770 created "2016-06-24" @default.
• W2080348770 creator A5012118769 @default.
• W2080348770 creator A5024069989 @default.
• W2080348770 creator A5040578272 @default.
• W2080348770 creator A5057833846 @default.
• W2080348770 creator A5081350762 @default.
• W2080348770 date "1967-08-01" @default.
• W2080348770 modified "2023-09-27" @default.
• W2080348770 title "The Seldinger Catheter in Radiation Therapy" @default.
• W2080348770 doi "https://doi.org/10.1148/89.2.332" @default.
• W2080348770 hasPublicationYear "1967" @default.
• W2080348770 type Work @default.
• W2080348770 sameAs 2080348770 @default.
• W2080348770 citedByCount "9" @default.
• W2080348770 crossrefType "journal-article" @default.
• W2080348770 hasAuthorship W2080348770A5012118769 @default.
• W2080348770 hasAuthorship W2080348770A5024069989 @default.
• W2080348770 hasAuthorship W2080348770A5040578272 @default.
• W2080348770 hasAuthorship W2080348770A5057833846 @default.
• W2080348770 hasAuthorship W2080348770A5081350762 @default.
• W2080348770 hasConcept C126322002 @default.
• W2080348770 hasConcept C126838900 @default.
• W2080348770 hasConcept C2775859304 @default.
• W2080348770 hasConcept C2776634560 @default.
• W2080348770 hasConcept C2780091579 @default.
• W2080348770 hasConcept C2780813298 @default.
• W2080348770 hasConcept C2989005 @default.
• W2080348770 hasConcept C509974204 @default.
• W2080348770 hasConcept C71924100 @default.
• W2080348770 hasConceptScore W2080348770C126322002 @default.
• W2080348770 hasConceptScore W2080348770C126838900 @default.
• W2080348770 hasConceptScore W2080348770C2775859304 @default.
• W2080348770 hasConceptScore W2080348770C2776634560 @default.
• W2080348770 hasConceptScore W2080348770C2780091579 @default.
• W2080348770 hasConceptScore W2080348770C2780813298 @default.
• W2080348770 hasConceptScore W2080348770C2989005 @default.
• W2080348770 hasConceptScore W2080348770C509974204 @default.
• W2080348770 hasConceptScore W2080348770C71924100 @default.
• W2080348770 hasIssue "2" @default.
• W2080348770 hasLocation W20803487701 @default.
• W2080348770 hasOpenAccess W2080348770 @default.
• W2080348770 hasPrimaryLocation W20803487701 @default.
• W2080348770 hasRelatedWork W1997169225 @default.
• W2080348770 hasRelatedWork W2081486883 @default.
• W2080348770 hasRelatedWork W2254408020 @default.
• W2080348770 hasRelatedWork W2338785145 @default.
• W2080348770 hasRelatedWork W2376313638 @default.
• W2080348770 hasRelatedWork W2395600221 @default.
• W2080348770 hasRelatedWork W2395644890 @default.
• W2080348770 hasRelatedWork W2442397302 @default.
• W2080348770 hasRelatedWork W2511813053 @default.
• W2080348770 hasRelatedWork W4290331825 @default.
• W2080348770 hasVolume "89" @default.
• W2080348770 isParatext "false" @default.
• W2080348770 isRetracted "false" @default.
• W2080348770 magId "2080348770" @default.
• W2080348770 workType "article" @default.