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- W2080349904 abstract "Abstract Four novel dicyclic arene–homospermidine conjugates (6a–d) were synthesized and evaluated for cytotoxicity in L1210, α-difluoromethylornithine (DFMO) treated L1210, melanoma B16, spermidine (SPD) treated B16, and Hela cells. In the DFMO-treated L1210 experiments, 6a–d were more sensitive to DFMO than naphthalene-homospermidine (6e), suggesting that 6a–d can utilize the polyamine transporter (PAT) to enter the cells as well as 6e. The diminished cytotoxicity in the SPD/B16 experiments also supported this conclusion. In summary, the homospermidine is an efficacious vector to ferry dicyclic arenes into cells via PAT." @default.
- W2080349904 created "2016-06-24" @default.
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- W2080349904 date "2007-08-01" @default.
- W2080349904 modified "2023-09-25" @default.
- W2080349904 title "The synthesis and bioevaluation of the dicyclic arene–homospermidine conjugates" @default.
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- W2080349904 doi "https://doi.org/10.1016/j.cclet.2007.05.053" @default.
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