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• W2080356726 abstract "Potential interaction of Aurora-A amplification and BRCA2 mutation was examined in breast tumours from BRCA2 999del5 mutation carriers (n = 20) and non-carriers (n = 41). Aurora-A amplification studied by FISH was significantly more common in breast tumours from BRCA2 mutation carriers (p = 0.0005). Extensive Aurora-A amplification was also detected on metaphase chromosomes in three breast epithelial cell lines with the same BRCA2 mutation. In addition, significant association was found between Aurora-A amplification and TP53 mutations in non-BRCA2 mutation carrier tumours (p = 0.007). These results suggest that breast tumours with mutations in BRCA2 or TP53 could be promising candidates for Aurora-A targeted treatment." @default.
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• W2080356726 date "2007-04-01" @default.
• W2080356726 modified "2023-10-16" @default.
• W2080356726 title "Aurora-A amplification associated with BRCA2 mutation in breast tumours" @default.
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• W2080356726 doi "https://doi.org/10.1016/j.canlet.2006.06.003" @default.
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