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• W2080358504 abstract "We have previously shown that Docetaxel‐induced variable degrees of apoptosis in melanoma. In this report, we studied the β‐tubulin repertoire of melanoma cell lines and show that class III β‐tubulin expression correlated with Docetaxel‐resistance. Sensitive cells showed low levels of class III β‐tubulin with little microtubular incorporation, whereas class III β‐tubulin expression was higher in resistant cells and was incorporated into the cytoskeleton. As proof of concept, abrogation of class III by siRNA reverted Docetaxel‐resistant cells to a sensitive phenotype, restoring the microtubular polymerisation response and promoting high levels of apoptosis through Bax activation. These results suggest that phenotypic expression of β‐tubulin class III in melanoma may help identify patients with melanoma that can respond to taxanes." @default.
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• W2080358504 date "2007-12-18" @default.
• W2080358504 modified "2023-10-17" @default.
• W2080358504 title "Melanoma cell sensitivity to Docetaxel-induced apoptosis is determined by class III β-tubulin levels" @default.
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• W2080358504 doi "https://doi.org/10.1016/j.febslet.2007.12.014" @default.
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