Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080359287> ?p ?o ?g. }
- W2080359287 endingPage "13" @default.
- W2080359287 startingPage "8" @default.
- W2080359287 abstract "Mechano-growth factor (MGF), an insulin-like growth factor-I (IGF-I) splice variant, often serves as an important local tissue repair factor in response to the mechanical environment. However, there is no model for exhibiting the MGF expression in a series of strain distribution up to now. In this study, a novel mechanical loading model containing different stresses and strains simultaneously was developed to examine the MGF expression. The strain distributions were predicted by finite element modeling. The MC3T3-E1 cells on a silicone membrane with a central circular hole were exposed to a variable strain environment through stretching. The finite element analysis showed that, when the strain reached the magnitude of 10%, the strain concentration near the circular hole displayed along with the vertical stretch direction, while the minimum strain appeared in the parallel stretch direction. Furthermore, the results showed that MGF expression decreased gradually from high to low strain regions by immunocytochemistry. Meanwhile, the proliferation of osteoblasts increased significantly in the high strain region. In conclusion, this mechanical loading model can present the different distributions of the strain of osteoblasts in vitro. MGF expression and osteoblast proliferation have a high correlation with the levels of strain." @default.
- W2080359287 created "2016-06-24" @default.
- W2080359287 creator A5008942164 @default.
- W2080359287 creator A5028444541 @default.
- W2080359287 creator A5046927155 @default.
- W2080359287 creator A5076054410 @default.
- W2080359287 creator A5080609518 @default.
- W2080359287 creator A5082827291 @default.
- W2080359287 creator A5090751121 @default.
- W2080359287 date "2011-07-01" @default.
- W2080359287 modified "2023-10-18" @default.
- W2080359287 title "A novel mechanical loading model for studying the distributions of strain and mechano-growth factor expression" @default.
- W2080359287 cites W1581593042 @default.
- W2080359287 cites W1593463348 @default.
- W2080359287 cites W1966308787 @default.
- W2080359287 cites W1969472947 @default.
- W2080359287 cites W1970086540 @default.
- W2080359287 cites W1974489896 @default.
- W2080359287 cites W1982479568 @default.
- W2080359287 cites W1987736832 @default.
- W2080359287 cites W1992882775 @default.
- W2080359287 cites W1996028216 @default.
- W2080359287 cites W2002934579 @default.
- W2080359287 cites W2008390931 @default.
- W2080359287 cites W2016944916 @default.
- W2080359287 cites W2020600683 @default.
- W2080359287 cites W2022389695 @default.
- W2080359287 cites W2023220045 @default.
- W2080359287 cites W2031790586 @default.
- W2080359287 cites W2035671623 @default.
- W2080359287 cites W2036100674 @default.
- W2080359287 cites W2048492086 @default.
- W2080359287 cites W2059865811 @default.
- W2080359287 cites W2060796830 @default.
- W2080359287 cites W2077004324 @default.
- W2080359287 cites W2079335233 @default.
- W2080359287 cites W2084805470 @default.
- W2080359287 cites W2091644363 @default.
- W2080359287 cites W2093421993 @default.
- W2080359287 cites W2102844239 @default.
- W2080359287 cites W2121242644 @default.
- W2080359287 cites W2126195223 @default.
- W2080359287 cites W2150793811 @default.
- W2080359287 cites W2154993264 @default.
- W2080359287 cites W2155594517 @default.
- W2080359287 doi "https://doi.org/10.1016/j.abb.2011.04.016" @default.
- W2080359287 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21550333" @default.
- W2080359287 hasPublicationYear "2011" @default.
- W2080359287 type Work @default.
- W2080359287 sameAs 2080359287 @default.
- W2080359287 citedByCount "14" @default.
- W2080359287 countsByYear W20803592872012 @default.
- W2080359287 countsByYear W20803592872013 @default.
- W2080359287 countsByYear W20803592872014 @default.
- W2080359287 countsByYear W20803592872015 @default.
- W2080359287 countsByYear W20803592872016 @default.
- W2080359287 countsByYear W20803592872017 @default.
- W2080359287 countsByYear W20803592872018 @default.
- W2080359287 countsByYear W20803592872019 @default.
- W2080359287 countsByYear W20803592872020 @default.
- W2080359287 countsByYear W20803592872021 @default.
- W2080359287 countsByYear W20803592872022 @default.
- W2080359287 crossrefType "journal-article" @default.
- W2080359287 hasAuthorship W2080359287A5008942164 @default.
- W2080359287 hasAuthorship W2080359287A5028444541 @default.
- W2080359287 hasAuthorship W2080359287A5046927155 @default.
- W2080359287 hasAuthorship W2080359287A5076054410 @default.
- W2080359287 hasAuthorship W2080359287A5080609518 @default.
- W2080359287 hasAuthorship W2080359287A5082827291 @default.
- W2080359287 hasAuthorship W2080359287A5090751121 @default.
- W2080359287 hasConcept C105702510 @default.
- W2080359287 hasConcept C12554922 @default.
- W2080359287 hasConcept C127413603 @default.
- W2080359287 hasConcept C134018914 @default.
- W2080359287 hasConcept C135628077 @default.
- W2080359287 hasConcept C170493617 @default.
- W2080359287 hasConcept C185592680 @default.
- W2080359287 hasConcept C192562407 @default.
- W2080359287 hasConcept C2775960820 @default.
- W2080359287 hasConcept C2778022156 @default.
- W2080359287 hasConcept C35866371 @default.
- W2080359287 hasConcept C55493867 @default.
- W2080359287 hasConcept C66938386 @default.
- W2080359287 hasConcept C86803240 @default.
- W2080359287 hasConceptScore W2080359287C105702510 @default.
- W2080359287 hasConceptScore W2080359287C12554922 @default.
- W2080359287 hasConceptScore W2080359287C127413603 @default.
- W2080359287 hasConceptScore W2080359287C134018914 @default.
- W2080359287 hasConceptScore W2080359287C135628077 @default.
- W2080359287 hasConceptScore W2080359287C170493617 @default.
- W2080359287 hasConceptScore W2080359287C185592680 @default.
- W2080359287 hasConceptScore W2080359287C192562407 @default.
- W2080359287 hasConceptScore W2080359287C2775960820 @default.
- W2080359287 hasConceptScore W2080359287C2778022156 @default.
- W2080359287 hasConceptScore W2080359287C35866371 @default.
- W2080359287 hasConceptScore W2080359287C55493867 @default.
- W2080359287 hasConceptScore W2080359287C66938386 @default.
- W2080359287 hasConceptScore W2080359287C86803240 @default.