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• W2080360315 abstract "Methanol is the organic solvent closest to water and able to dissolve a huge amount of organic compounds. Therefore, it is a good candidate for pK(a) determination of drugs sparingly soluble in water or a basic drug presented as a salt which pK(a) is close to that of its counter-acid. In this work, the acidic dissociation constants in pure methanol of the most common acids used in pharmaceutical preparations (lactic, tartaric, fumaric, maleic and citric) were determined. In addition, the pK(a) values of the antipsychotic quetiapine presented as hemifumarate (Seroquel) and the very insoluble antiarrhythmic amiodarone were also determined by potentiometry. From these values, the aqueous pK(a) of these drugs were estimated by means of previously established equations. Estimated values are consistent with those from literature and show the interest of methanol for drug discovery pK(a) measurements." @default.
• W2080360315 created "2016-06-24" @default.
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• W2080360315 date "2007-08-15" @default.
• W2080360315 modified "2023-09-24" @default.
• W2080360315 title "Acidity of several polyprotic acids, amiodarone and quetiapine hemifumarate in pure methanol" @default.
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• W2080360315 doi "https://doi.org/10.1016/j.talanta.2007.03.010" @default.
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