FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080361330> ?p ?o ?g. }

• W2080361330 endingPage "804" @default.
• W2080361330 startingPage "788" @default.
• W2080361330 abstract "There is clear evidence of genetic modulation of bone phenotype parameters including bone density, quantitative ultrasound, bone size, and bone turnover. At any particular age and phase of life, genetic factors explain about 70% of the variance in bone phenotype after adjustment for major medical and disease factors. Hormonal factors, diet, and lifestyle interact with those genetic factors over time. Common allelic variation in the VDR was the first of several genes and now chromosomal loci to be implicated in the genetic determination of bone phenotype. The VDR polymorphisms have an effect weaker than originally reported, and part of the allelic effects may be mediated by effects on body size and development and even other hormonal regulators such as PTH or insulin. Irrespective of the strength or mechanism of these associations, these initial findings on the VDR stimulated the field of the genetics of osteoporosis with targeted genetic studies and now genome scan approaches. Intronic polymorphisms of the collagen I alpha 1 gene have been shown to be related to bone density and to fracture risk in several studies, although not all findings concur. Common allelic variations have now been associated with bone density for the estrogen receptor, TGF beta receptor, and TGF beta 1, for the insulin-like growth factor-I pathway, for interleukin-4 and -6 and the interleukin-1 receptor antagonist, for calcitonin and the PTH receptors and for apolipoprotein E. Of considerable interest, chromosomal loci, notably 11q 12-13, have now been linked to bone phenotypes in human and mouse studies. The mouse strain studies seem likely to be powerful tools providing insight to important human loci based on the mouse-human chromosomal synteny. Variability of genetic findings across studies seems to be the rule rather than the exception. This variability may relate to interaction of particular loci with specific environmental or even other genetic loci. The importance of genetic heterogeneity, including ethnicity, as well as environmental and hormonal confounders, such as calcium and vitamin D intake, hormonal status and skeletal and body size, will need to be taken into account in future gene search approaches. Genome scans in relation to bone density and fracture end-points will need to account for such important potential confounders in each target population. Interactions between genetic and environmental factors, including lifestyle, have been investigated initially for the VDR polymorphisms in relation to the response of bone density and turnover to calcium intake and treatment with simple vitamin D and active vitamin D compounds. Gene-gene and gene-environment interactions in human and animal models will be critical targets for future research. Further genes with positive and negative effects on bone phenotype are certain to be identified in the near future. Each of these will need to be evaluated in relation to potential environmental modulators in pharmacogenetic models. Understanding the molecular physiology of such gene effects is likely to lead to more specific treatments and to allow the selection of more appropriate and effective treatment options." @default.
• W2080361330 created "2016-06-24" @default.
• W2080361330 creator A5080737658 @default.
• W2080361330 date "1999-12-01" @default.
• W2080361330 modified "2023-10-09" @default.
• W2080361330 title "Genetics of Osteoporosis" @default.
• W2080361330 cites W1681803642 @default.
• W2080361330 cites W188629261 @default.
• W2080361330 cites W1911877181 @default.
• W2080361330 cites W1952095135 @default.
• W2080361330 cites W1966411863 @default.
• W2080361330 cites W1970001479 @default.
• W2080361330 cites W1970704850 @default.
• W2080361330 cites W1974619793 @default.
• W2080361330 cites W1975326550 @default.
• W2080361330 cites W1975684279 @default.
• W2080361330 cites W1975898948 @default.
• W2080361330 cites W1976299374 @default.
• W2080361330 cites W1976353096 @default.
• W2080361330 cites W1976479551 @default.
• W2080361330 cites W1976640699 @default.
• W2080361330 cites W1977063684 @default.
• W2080361330 cites W1979344569 @default.
• W2080361330 cites W1979710363 @default.
• W2080361330 cites W1979748103 @default.
• W2080361330 cites W1982376401 @default.
• W2080361330 cites W1984140102 @default.
• W2080361330 cites W1984223009 @default.
• W2080361330 cites W1984274121 @default.
• W2080361330 cites W1984941837 @default.
• W2080361330 cites W1985061152 @default.
• W2080361330 cites W1985184665 @default.
• W2080361330 cites W1985598913 @default.
• W2080361330 cites W1986138660 @default.
• W2080361330 cites W1986238913 @default.
• W2080361330 cites W1986444749 @default.
• W2080361330 cites W1986455710 @default.
• W2080361330 cites W1987710313 @default.
• W2080361330 cites W1990034002 @default.
• W2080361330 cites W1990442559 @default.
• W2080361330 cites W1990847484 @default.
• W2080361330 cites W1992695991 @default.
• W2080361330 cites W1993231839 @default.
• W2080361330 cites W1994601674 @default.
• W2080361330 cites W1994841755 @default.
• W2080361330 cites W1995545002 @default.
• W2080361330 cites W1995761871 @default.
• W2080361330 cites W1996109272 @default.
• W2080361330 cites W1996117226 @default.
• W2080361330 cites W1996707061 @default.
• W2080361330 cites W1996857967 @default.
• W2080361330 cites W1997411213 @default.
• W2080361330 cites W1997883187 @default.
• W2080361330 cites W1998945321 @default.
• W2080361330 cites W1999365080 @default.
• W2080361330 cites W1999876261 @default.
• W2080361330 cites W2000222427 @default.
• W2080361330 cites W2001024743 @default.
• W2080361330 cites W2001100003 @default.
• W2080361330 cites W2001923371 @default.
• W2080361330 cites W2002765364 @default.
• W2080361330 cites W2003112481 @default.
• W2080361330 cites W2004389367 @default.
• W2080361330 cites W2004600627 @default.
• W2080361330 cites W2005684226 @default.
• W2080361330 cites W2005936777 @default.
• W2080361330 cites W2007442064 @default.
• W2080361330 cites W2007581763 @default.
• W2080361330 cites W2009180025 @default.
• W2080361330 cites W2010868848 @default.
• W2080361330 cites W2011195601 @default.
• W2080361330 cites W2014369347 @default.
• W2080361330 cites W2014590517 @default.
• W2080361330 cites W2015497941 @default.
• W2080361330 cites W2015703307 @default.
• W2080361330 cites W2015950286 @default.
• W2080361330 cites W2016003183 @default.
• W2080361330 cites W2016151434 @default.
• W2080361330 cites W2017464232 @default.
• W2080361330 cites W2017467381 @default.
• W2080361330 cites W2017842476 @default.
• W2080361330 cites W2018758479 @default.
• W2080361330 cites W2019117192 @default.
• W2080361330 cites W2019312798 @default.
• W2080361330 cites W2020831981 @default.
• W2080361330 cites W2021877002 @default.
• W2080361330 cites W2021895727 @default.
• W2080361330 cites W2022189136 @default.
• W2080361330 cites W2023018474 @default.
• W2080361330 cites W2023086815 @default.
• W2080361330 cites W2023184872 @default.
• W2080361330 cites W2023446056 @default.
• W2080361330 cites W2027938230 @default.
• W2080361330 cites W2029748211 @default.
• W2080361330 cites W2030681414 @default.
• W2080361330 cites W2032573466 @default.
• W2080361330 cites W2032821264 @default.
• W2080361330 cites W2032917145 @default.

• next