FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080365739> ?p ?o ?g. }

• W2080365739 endingPage "2035" @default.
• W2080365739 startingPage "2028" @default.
• W2080365739 abstract "Despite the success of abciximab in preventing ischemic events after percutaneous coronary interventions, attempts to develop intravenous, small-molecule glycoprotein IIb/IIIa antagonists and diversify the clinical indications for these agents have produced varied results. The 30-day ischemic event reduction in the percutaneous coronary intervention trials has ranged by over three-fold (16% to 56%) and is greater among the acute coronary syndrome trials. The phase III trials exploring the role of oral glycoprotein IIb/IIIa inhibition have been consistently disappointing, with evolving evidence of increased mortality. Mechanisms contributing to these heterogeneous results may include normal variation in platelet or receptor number, differences in receptor activity, interpatient variation in pharmacological dose-response and the possibility of prothrombotic or nonglycoprotein IIb/IIIa effects. Plausibility of suboptimal effect is suggested by several recent studies. Trials investigating the role of intravenous small-molecule IIb/IIIa antagonists highlight the importance of effective dosing. The increase in bleeding and mortality observed in the oral glycoprotein IIb/IIIa studies indicate the consequences of suboptimal dosing on safety on one hand, while raising the possibility of important prothrombotic, counterregulatory or other sudden cardiac events. This article will undertake a review of the relevant platelet biology, discuss the mechanisms that may contribute to suboptimal antiplatelet efficacy with these agents and examine insights from the clinical trials supporting these concepts." @default.
• W2080365739 created "2016-06-24" @default.
• W2080365739 creator A5037363092 @default.
• W2080365739 creator A5048065442 @default.
• W2080365739 date "2000-12-01" @default.
• W2080365739 modified "2023-10-10" @default.
• W2080365739 title "A critical appraisal of platelet glycoprotein IIb/IIIa inhibition" @default.
• W2080365739 cites W1509179347 @default.
• W2080365739 cites W1602182436 @default.
• W2080365739 cites W1667478348 @default.
• W2080365739 cites W1817907600 @default.
• W2080365739 cites W1918399424 @default.
• W2080365739 cites W1925247341 @default.
• W2080365739 cites W1972109636 @default.
• W2080365739 cites W1989381306 @default.
• W2080365739 cites W2000205702 @default.
• W2080365739 cites W2000678106 @default.
• W2080365739 cites W2012691080 @default.
• W2080365739 cites W2013373630 @default.
• W2080365739 cites W2015182475 @default.
• W2080365739 cites W2022814481 @default.
• W2080365739 cites W2023252309 @default.
• W2080365739 cites W2028202875 @default.
• W2080365739 cites W2033476357 @default.
• W2080365739 cites W2037545303 @default.
• W2080365739 cites W2052899600 @default.
• W2080365739 cites W2053917461 @default.
• W2080365739 cites W2056852724 @default.
• W2080365739 cites W2061016886 @default.
• W2080365739 cites W2064739148 @default.
• W2080365739 cites W2073797855 @default.
• W2080365739 cites W2078253165 @default.
• W2080365739 cites W2081258799 @default.
• W2080365739 cites W2082248307 @default.
• W2080365739 cites W2087305090 @default.
• W2080365739 cites W2095414565 @default.
• W2080365739 cites W2109691078 @default.
• W2080365739 cites W2116687459 @default.
• W2080365739 cites W2116897563 @default.
• W2080365739 cites W2123490492 @default.
• W2080365739 cites W2124788115 @default.
• W2080365739 cites W2126860015 @default.
• W2080365739 cites W2128654223 @default.
• W2080365739 cites W2136516470 @default.
• W2080365739 cites W2141117188 @default.
• W2080365739 cites W2230838014 @default.
• W2080365739 cites W2281862598 @default.
• W2080365739 cites W2313726388 @default.
• W2080365739 cites W2324899882 @default.
• W2080365739 cites W2329622594 @default.
• W2080365739 cites W2395047360 @default.
• W2080365739 cites W2395313915 @default.
• W2080365739 cites W241504982 @default.
• W2080365739 cites W2523247802 @default.
• W2080365739 cites W2619044267 @default.
• W2080365739 cites W2622930465 @default.
• W2080365739 cites W3022148767 @default.
• W2080365739 cites W4237482550 @default.
• W2080365739 cites W4237892021 @default.
• W2080365739 cites W4256202725 @default.
• W2080365739 doi "https://doi.org/10.1016/s0735-1097(00)00979-7" @default.
• W2080365739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11127436" @default.
• W2080365739 hasPublicationYear "2000" @default.
• W2080365739 type Work @default.
• W2080365739 sameAs 2080365739 @default.
• W2080365739 citedByCount "63" @default.
• W2080365739 countsByYear W20803657392013 @default.
• W2080365739 countsByYear W20803657392014 @default.
• W2080365739 countsByYear W20803657392015 @default.
• W2080365739 countsByYear W20803657392016 @default.
• W2080365739 countsByYear W20803657392018 @default.
• W2080365739 countsByYear W20803657392019 @default.
• W2080365739 crossrefType "journal-article" @default.
• W2080365739 hasAuthorship W2080365739A5037363092 @default.
• W2080365739 hasAuthorship W2080365739A5048065442 @default.
• W2080365739 hasConcept C126322002 @default.
• W2080365739 hasConcept C142724271 @default.
• W2080365739 hasConcept C152541439 @default.
• W2080365739 hasConcept C164705383 @default.
• W2080365739 hasConcept C177713679 @default.
• W2080365739 hasConcept C204787440 @default.
• W2080365739 hasConcept C2777288759 @default.
• W2080365739 hasConcept C2777698277 @default.
• W2080365739 hasConcept C2777871224 @default.
• W2080365739 hasConcept C2780400711 @default.
• W2080365739 hasConcept C500558357 @default.
• W2080365739 hasConcept C535046627 @default.
• W2080365739 hasConcept C71924100 @default.
• W2080365739 hasConcept C89560881 @default.
• W2080365739 hasConcept C98274493 @default.
• W2080365739 hasConceptScore W2080365739C126322002 @default.
• W2080365739 hasConceptScore W2080365739C142724271 @default.
• W2080365739 hasConceptScore W2080365739C152541439 @default.
• W2080365739 hasConceptScore W2080365739C164705383 @default.
• W2080365739 hasConceptScore W2080365739C177713679 @default.
• W2080365739 hasConceptScore W2080365739C204787440 @default.
• W2080365739 hasConceptScore W2080365739C2777288759 @default.
• W2080365739 hasConceptScore W2080365739C2777698277 @default.

• next