Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080366857> ?p ?o ?g. }
- W2080366857 endingPage "138" @default.
- W2080366857 startingPage "131" @default.
- W2080366857 abstract "The present paper reports on two investigations designed with the aim of refining existing animal models representing several aspects of psychosis, used to evaluate antipsychotic potential of novel compounds. The aim of the first investigation was to determine the effect of habituating rats to the injection procedure on three behavioural testing paradigms, social interaction, locomotor activity and prepulse inhibition (PPI) of the acoustic startle response. Results showed that while there was no effect on social behaviour or locomotor activity, the habituating to injection procedure decreased startle magnitude. For the second study, the aim was to determine whether the order in which the tests were conducted would affect sensitivity to the effects of dizocilpine (MK-801), a non-competitive NMDA receptor antagonist known to induce social withdrawal, increase locomotor activity and disrupt PPI. Either social interaction or locomotor activity tests were carried out 3 days prior to PPI tests (protocol 1), or PPI tests were carried out 3 days prior to social interaction and locomotor activity tests (protocol 2). Results showed that protocol 2 rats were more sensitive to the social withdrawal-inducing, hyperlocomotive- and PPI-disruptive effects of MK-801. Based on these results, the testing conditions appear to have a significant influence on the outcome of experiments aimed at observing the propsychotic action of MK-801." @default.
- W2080366857 created "2016-06-24" @default.
- W2080366857 creator A5028326172 @default.
- W2080366857 creator A5035585145 @default.
- W2080366857 creator A5041696130 @default.
- W2080366857 date "2010-01-01" @default.
- W2080366857 modified "2023-09-26" @default.
- W2080366857 title "Effect of testing conditions on the propsychotic action of MK-801 on prepulse inhibition, social behaviour and locomotor activity" @default.
- W2080366857 cites W1968524760 @default.
- W2080366857 cites W1969009914 @default.
- W2080366857 cites W1970304473 @default.
- W2080366857 cites W1971194855 @default.
- W2080366857 cites W1972751263 @default.
- W2080366857 cites W1979656019 @default.
- W2080366857 cites W1979844761 @default.
- W2080366857 cites W1988299084 @default.
- W2080366857 cites W1990580330 @default.
- W2080366857 cites W1990888488 @default.
- W2080366857 cites W1990965860 @default.
- W2080366857 cites W1993823352 @default.
- W2080366857 cites W1993855559 @default.
- W2080366857 cites W2003935114 @default.
- W2080366857 cites W2012074766 @default.
- W2080366857 cites W2012105955 @default.
- W2080366857 cites W2019442403 @default.
- W2080366857 cites W2025055494 @default.
- W2080366857 cites W2032193303 @default.
- W2080366857 cites W2040646852 @default.
- W2080366857 cites W2040856930 @default.
- W2080366857 cites W2044598463 @default.
- W2080366857 cites W2048027719 @default.
- W2080366857 cites W2054594645 @default.
- W2080366857 cites W2058083741 @default.
- W2080366857 cites W2061408393 @default.
- W2080366857 cites W2062777192 @default.
- W2080366857 cites W2064776106 @default.
- W2080366857 cites W2066838264 @default.
- W2080366857 cites W2068337150 @default.
- W2080366857 cites W2074455476 @default.
- W2080366857 cites W2082145766 @default.
- W2080366857 cites W2088620464 @default.
- W2080366857 cites W2089354797 @default.
- W2080366857 cites W2090287898 @default.
- W2080366857 cites W2097759310 @default.
- W2080366857 cites W2123923673 @default.
- W2080366857 cites W2139606243 @default.
- W2080366857 cites W2147447711 @default.
- W2080366857 cites W2169055778 @default.
- W2080366857 cites W2318210124 @default.
- W2080366857 cites W2395499779 @default.
- W2080366857 cites W4211032287 @default.
- W2080366857 doi "https://doi.org/10.1016/j.physbeh.2009.11.005" @default.
- W2080366857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19931287" @default.
- W2080366857 hasPublicationYear "2010" @default.
- W2080366857 type Work @default.
- W2080366857 sameAs 2080366857 @default.
- W2080366857 citedByCount "21" @default.
- W2080366857 countsByYear W20803668572012 @default.
- W2080366857 countsByYear W20803668572013 @default.
- W2080366857 countsByYear W20803668572014 @default.
- W2080366857 countsByYear W20803668572015 @default.
- W2080366857 countsByYear W20803668572018 @default.
- W2080366857 countsByYear W20803668572019 @default.
- W2080366857 countsByYear W20803668572021 @default.
- W2080366857 countsByYear W20803668572022 @default.
- W2080366857 crossrefType "journal-article" @default.
- W2080366857 hasAuthorship W2080366857A5028326172 @default.
- W2080366857 hasAuthorship W2080366857A5035585145 @default.
- W2080366857 hasAuthorship W2080366857A5041696130 @default.
- W2080366857 hasConcept C118552586 @default.
- W2080366857 hasConcept C126322002 @default.
- W2080366857 hasConcept C130064352 @default.
- W2080366857 hasConcept C138496976 @default.
- W2080366857 hasConcept C141421786 @default.
- W2080366857 hasConcept C15744967 @default.
- W2080366857 hasConcept C169760540 @default.
- W2080366857 hasConcept C170493617 @default.
- W2080366857 hasConcept C2776035688 @default.
- W2080366857 hasConcept C2776412080 @default.
- W2080366857 hasConcept C2776885963 @default.
- W2080366857 hasConcept C2777836312 @default.
- W2080366857 hasConcept C2777845764 @default.
- W2080366857 hasConcept C2779727114 @default.
- W2080366857 hasConcept C2780494398 @default.
- W2080366857 hasConcept C2993436365 @default.
- W2080366857 hasConcept C46312422 @default.
- W2080366857 hasConcept C67018056 @default.
- W2080366857 hasConcept C71924100 @default.
- W2080366857 hasConcept C77805123 @default.
- W2080366857 hasConcept C98274493 @default.
- W2080366857 hasConceptScore W2080366857C118552586 @default.
- W2080366857 hasConceptScore W2080366857C126322002 @default.
- W2080366857 hasConceptScore W2080366857C130064352 @default.
- W2080366857 hasConceptScore W2080366857C138496976 @default.
- W2080366857 hasConceptScore W2080366857C141421786 @default.
- W2080366857 hasConceptScore W2080366857C15744967 @default.
- W2080366857 hasConceptScore W2080366857C169760540 @default.
- W2080366857 hasConceptScore W2080366857C170493617 @default.