Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080371301> ?p ?o ?g. }
- W2080371301 endingPage "125" @default.
- W2080371301 startingPage "114" @default.
- W2080371301 abstract "Spinal cord injury (SCI) leads to formation of a fibrotic scar that is inhibitory to axon regeneration. Recent evidence indicates that the fibrotic scar is formed by perivascular fibroblasts, but the mechanism by which they are recruited to the injury site is unknown. Using bone marrow transplantation in mouse model of spinal cord injury, we show that fibroblasts in the fibrotic scar are associated with hematogenous macrophages rather than microglia, which are limited to the surrounding astroglial scar. Depletion of hematogenous macrophages results in reduced fibroblast density and basal lamina formation that is associated with increased axonal growth in the fibrotic scar. Cytokine gene expression analysis after macrophage depletion indicates that decreased Tnfsf8, Tnfsf13 (tumor necrosis factor superfamily members) and increased BMP1-7 (bone morphogenetic proteins) expression may serve as anti-fibrotic mechanisms. Our study demonstrates that hematogenous macrophages are necessary for fibrotic scar formation and macrophage depletion results in changes in multiple cytokines that make the injury site less fibrotic and more conducive to axonal growth." @default.
- W2080371301 created "2016-06-24" @default.
- W2080371301 creator A5028148320 @default.
- W2080371301 creator A5029099927 @default.
- W2080371301 creator A5033396109 @default.
- W2080371301 creator A5040756585 @default.
- W2080371301 creator A5058495338 @default.
- W2080371301 creator A5087327742 @default.
- W2080371301 date "2015-02-01" @default.
- W2080371301 modified "2023-10-18" @default.
- W2080371301 title "Hematogenous macrophage depletion reduces the fibrotic scar and increases axonal growth after spinal cord injury" @default.
- W2080371301 cites W1483863796 @default.
- W2080371301 cites W1688463639 @default.
- W2080371301 cites W1905312869 @default.
- W2080371301 cites W1963777718 @default.
- W2080371301 cites W1968013691 @default.
- W2080371301 cites W1968314732 @default.
- W2080371301 cites W1969444386 @default.
- W2080371301 cites W1974172728 @default.
- W2080371301 cites W1975751591 @default.
- W2080371301 cites W1976363248 @default.
- W2080371301 cites W1978597545 @default.
- W2080371301 cites W1979165828 @default.
- W2080371301 cites W1983325630 @default.
- W2080371301 cites W1986586948 @default.
- W2080371301 cites W1990946292 @default.
- W2080371301 cites W1992393249 @default.
- W2080371301 cites W1992613114 @default.
- W2080371301 cites W1992972508 @default.
- W2080371301 cites W1996199386 @default.
- W2080371301 cites W2002869490 @default.
- W2080371301 cites W2004041535 @default.
- W2080371301 cites W2010956007 @default.
- W2080371301 cites W2031399191 @default.
- W2080371301 cites W2047585900 @default.
- W2080371301 cites W2049555570 @default.
- W2080371301 cites W2059028717 @default.
- W2080371301 cites W2065577291 @default.
- W2080371301 cites W2080853291 @default.
- W2080371301 cites W2084169464 @default.
- W2080371301 cites W2091998173 @default.
- W2080371301 cites W2095263564 @default.
- W2080371301 cites W2095339919 @default.
- W2080371301 cites W2107058921 @default.
- W2080371301 cites W2118977333 @default.
- W2080371301 cites W2119742386 @default.
- W2080371301 cites W2123442007 @default.
- W2080371301 cites W2130529018 @default.
- W2080371301 cites W2136823896 @default.
- W2080371301 cites W2153406260 @default.
- W2080371301 cites W2156757115 @default.
- W2080371301 cites W2161057248 @default.
- W2080371301 cites W2333740675 @default.
- W2080371301 cites W2413769807 @default.
- W2080371301 cites W52558577 @default.
- W2080371301 doi "https://doi.org/10.1016/j.nbd.2014.10.024" @default.
- W2080371301 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4323620" @default.
- W2080371301 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25461258" @default.
- W2080371301 hasPublicationYear "2015" @default.
- W2080371301 type Work @default.
- W2080371301 sameAs 2080371301 @default.
- W2080371301 citedByCount "133" @default.
- W2080371301 countsByYear W20803713012016 @default.
- W2080371301 countsByYear W20803713012017 @default.
- W2080371301 countsByYear W20803713012018 @default.
- W2080371301 countsByYear W20803713012019 @default.
- W2080371301 countsByYear W20803713012020 @default.
- W2080371301 countsByYear W20803713012021 @default.
- W2080371301 countsByYear W20803713012022 @default.
- W2080371301 countsByYear W20803713012023 @default.
- W2080371301 crossrefType "journal-article" @default.
- W2080371301 hasAuthorship W2080371301A5028148320 @default.
- W2080371301 hasAuthorship W2080371301A5029099927 @default.
- W2080371301 hasAuthorship W2080371301A5033396109 @default.
- W2080371301 hasAuthorship W2080371301A5040756585 @default.
- W2080371301 hasAuthorship W2080371301A5058495338 @default.
- W2080371301 hasAuthorship W2080371301A5087327742 @default.
- W2080371301 hasBestOaLocation W20803713013 @default.
- W2080371301 hasConcept C105702510 @default.
- W2080371301 hasConcept C118552586 @default.
- W2080371301 hasConcept C142724271 @default.
- W2080371301 hasConcept C171056886 @default.
- W2080371301 hasConcept C17991360 @default.
- W2080371301 hasConcept C202751555 @default.
- W2080371301 hasConcept C203014093 @default.
- W2080371301 hasConcept C2776914184 @default.
- W2080371301 hasConcept C2777594495 @default.
- W2080371301 hasConcept C2778334475 @default.
- W2080371301 hasConcept C2779244956 @default.
- W2080371301 hasConcept C2779530196 @default.
- W2080371301 hasConcept C2779830541 @default.
- W2080371301 hasConcept C2780775167 @default.
- W2080371301 hasConcept C55493867 @default.
- W2080371301 hasConcept C71924100 @default.
- W2080371301 hasConcept C86803240 @default.
- W2080371301 hasConcept C95444343 @default.
- W2080371301 hasConceptScore W2080371301C105702510 @default.
- W2080371301 hasConceptScore W2080371301C118552586 @default.