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• W2080375542 abstract "Rationale: Although interferon (IFN)-γ release assays are approved for the diagnosis of latent tuberculosis infection (LTBI), limited data exist regarding their performance in HIV infection.Objectives: To compare tuberculin skin test (TST) results to the commercial IFN-γ release assay QuantiFERON-TB Gold In-Tube (QFT) for the diagnosis of LTBI in HIV-infected adults.Methods: A total of 294 HIV-infected subjects sampled from two San Francisco cohorts underwent TST, using 5 TU of purified protein derivative, and QFT, measuring IFN-γ response to Mycobacterium tuberculosis–specific RD-1 antigens.Main Results: Of 294 participants, 205 (70%) returned for an evaluable TST. Concordance between QFT and TST was 89.3% (kappa = 0.37, p = 0.007). However, in subjects with positive test results by either TST or QFT, only 28% (8/29) had positive test results by both modalities. TST-positive/QFT-negative discordant results were found in 5.1% of subjects and TST-negative/QFT-positive discordance in 5.6%. Indeterminate QFT results occurred in 5.1%, all due to a failure to respond to the phytohemagglutinin-positive control. Subjects with a CD4+ count of less than 100 cells/mm3 had a relative risk of an indeterminate result of 4.24 (95% confidence interval, 1.55–11.61; p= 0.003) compared with those with a CD4+ count of 100 or more.Conclusions: Overall concordance between QFT and TST in HIV infection was high, but agreement among subjects with positive tests by either modality was low." @default.
• W2080375542 created "2016-06-24" @default.
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• W2080375542 date "2007-04-01" @default.
• W2080375542 modified "2023-09-23" @default.
• W2080375542 title "Comparison of an Interferon-γ Release Assay with Tuberculin Skin Testing in HIV-infected Individuals" @default.
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• W2080375542 doi "https://doi.org/10.1164/rccm.200608-1088oc" @default.
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