Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080379602> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2080379602 endingPage "10" @default.
- W2080379602 startingPage "1" @default.
- W2080379602 abstract "We present a computer-based mathematical model that can simulate characteristic features of the clinical time course of human myeloma. It asserts that therapy resistance in myeloma cells is an inherited trait associated with the longer inter-mitotic times of some cells and that the strength of this trait affects tumour growth characteristics. These kinetic differences within the malignant cell clone may also influence therapeutic efficacy. In the model, the same total therapy, administered in different time-dose fractions, could be 'curative' or 'minimally effective' depending on kinetic properties. For example, as others have shown, in myeloma pulsed intermittent therapy is often more effective than low dose continuous therapy. According to our model this finding is compatible with a high coefficient of inheritability of resistance from one cell generation to the next. The model also suggests that if there are subclones of varying resistance, a therapy must have some effect on each of them if it is to be employed in a curative fashion. While many aspects of the model are not yet clinically testable, exploration of its concepts might increase knowledge about fundamental neoplastic mechanisms." @default.
- W2080379602 created "2016-06-24" @default.
- W2080379602 creator A5006009657 @default.
- W2080379602 creator A5015827324 @default.
- W2080379602 creator A5038348446 @default.
- W2080379602 creator A5039804973 @default.
- W2080379602 creator A5063242596 @default.
- W2080379602 date "1986-01-01" @default.
- W2080379602 modified "2023-09-24" @default.
- W2080379602 title "Mathematical Model For Human Myeloma Relating Growth Kinetics and Drug Resistance" @default.
- W2080379602 cites W1481415973 @default.
- W2080379602 cites W1580756501 @default.
- W2080379602 cites W1970543184 @default.
- W2080379602 cites W1984912638 @default.
- W2080379602 cites W2016776350 @default.
- W2080379602 cites W2017004780 @default.
- W2080379602 cites W2023728160 @default.
- W2080379602 cites W2034093057 @default.
- W2080379602 cites W2046872475 @default.
- W2080379602 cites W2062707603 @default.
- W2080379602 cites W2067590986 @default.
- W2080379602 cites W2081457935 @default.
- W2080379602 cites W2273737858 @default.
- W2080379602 cites W4238689661 @default.
- W2080379602 doi "https://doi.org/10.1111/j.1365-2184.1986.tb00710.x" @default.
- W2080379602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3955625" @default.
- W2080379602 hasPublicationYear "1986" @default.
- W2080379602 type Work @default.
- W2080379602 sameAs 2080379602 @default.
- W2080379602 citedByCount "2" @default.
- W2080379602 crossrefType "journal-article" @default.
- W2080379602 hasAuthorship W2080379602A5006009657 @default.
- W2080379602 hasAuthorship W2080379602A5015827324 @default.
- W2080379602 hasAuthorship W2080379602A5038348446 @default.
- W2080379602 hasAuthorship W2080379602A5039804973 @default.
- W2080379602 hasAuthorship W2080379602A5063242596 @default.
- W2080379602 hasConcept C104317684 @default.
- W2080379602 hasConcept C114851261 @default.
- W2080379602 hasConcept C203014093 @default.
- W2080379602 hasConcept C2776364478 @default.
- W2080379602 hasConcept C502942594 @default.
- W2080379602 hasConcept C54355233 @default.
- W2080379602 hasConcept C70721500 @default.
- W2080379602 hasConcept C81089528 @default.
- W2080379602 hasConcept C86803240 @default.
- W2080379602 hasConceptScore W2080379602C104317684 @default.
- W2080379602 hasConceptScore W2080379602C114851261 @default.
- W2080379602 hasConceptScore W2080379602C203014093 @default.
- W2080379602 hasConceptScore W2080379602C2776364478 @default.
- W2080379602 hasConceptScore W2080379602C502942594 @default.
- W2080379602 hasConceptScore W2080379602C54355233 @default.
- W2080379602 hasConceptScore W2080379602C70721500 @default.
- W2080379602 hasConceptScore W2080379602C81089528 @default.
- W2080379602 hasConceptScore W2080379602C86803240 @default.
- W2080379602 hasIssue "1" @default.
- W2080379602 hasLocation W20803796021 @default.
- W2080379602 hasLocation W20803796022 @default.
- W2080379602 hasOpenAccess W2080379602 @default.
- W2080379602 hasPrimaryLocation W20803796021 @default.
- W2080379602 hasRelatedWork W1966363271 @default.
- W2080379602 hasRelatedWork W1993970587 @default.
- W2080379602 hasRelatedWork W2030881267 @default.
- W2080379602 hasRelatedWork W2078811617 @default.
- W2080379602 hasRelatedWork W2080417264 @default.
- W2080379602 hasRelatedWork W2089685113 @default.
- W2080379602 hasRelatedWork W2139212458 @default.
- W2080379602 hasRelatedWork W2309652504 @default.
- W2080379602 hasRelatedWork W2398463189 @default.
- W2080379602 hasRelatedWork W2416559392 @default.
- W2080379602 hasVolume "19" @default.
- W2080379602 isParatext "false" @default.
- W2080379602 isRetracted "false" @default.
- W2080379602 magId "2080379602" @default.
- W2080379602 workType "article" @default.