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- W2080379664 abstract "Pertussis is still occurring in highly vaccinated populations, affecting individuals of all ages. Long-lived Th1 CD4(+) T cells are essential for protective immunity against pertussis. For better understanding of the limited immunological memory to Bordetella pertussis, we used a panel of Pertactin and Pertussis toxin specific peptides to interrogate CD4(+) T cell responses at the epitope level in a unique cohort of symptomatic pertussis patients of different ages, at various time intervals after infection. Our study showed that pertussis epitope-specific T cell responses contained Th1 and Th2 components irrespective of the epitope studied, time after infection, or age. In contrast, the breadth of the pertussis-directed CD4(+) T cell response seemed dependent on age and closeness to infection. Multi-epitope specificity long-term after infection was lost in older age groups. Detailed knowledge on pertussis specific immune mechanisms and their insufficiencies is important for understanding resurgence of pertussis in highly vaccinated populations." @default.
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- W2080379664 date "2013-12-31" @default.
- W2080379664 modified "2023-10-18" @default.
- W2080379664 title "Loss of Multi-Epitope Specificity in Memory CD4+ T Cell Responses to B. Pertussis with Age" @default.
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- W2080379664 doi "https://doi.org/10.1371/journal.pone.0083583" @default.
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