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- W2080381817 endingPage "477" @default.
- W2080381817 startingPage "465" @default.
- W2080381817 abstract "The mammalian brain and spinal cord contain heterogeneous populations of cycling, immature cells. These include cells with stem cell-like properties as well as progenitors in various stages of early glial differentiation. This latter population is distributed widely throughout gray and white matter and numerically represents an extremely large cell pool. In this review, we discuss the possibility that the glial progenitors that populate the adult CNS are one source of gliomas. Indeed, the marker phenotypes, morphologies, and migratory properties of cells in gliomas strongly resemble glial progenitors in many ways. We review briefly some salient features of normal glial development and then examine the similarities and differences between normal progenitors and cells in gliomas, focusing on the phenotypic plasticity of glial progenitors and the responses to growth factors in promoting proliferation and migration of normal and glioma cells, and discussing known mutational changes in gliomas in the context of how these might affect the proliferative and migratory behaviors of progenitors. Finally, we will discuss the “cancer stem cell” hypothesis in light of the possibility that glial progenitors can generate gliomas." @default.
- W2080381817 created "2016-06-24" @default.
- W2080381817 creator A5011457832 @default.
- W2080381817 creator A5046673359 @default.
- W2080381817 date "2008-09-11" @default.
- W2080381817 modified "2023-10-04" @default.
- W2080381817 title "The interface between glial progenitors and gliomas" @default.
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