FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080382069> ?p ?o ?g. }

• W2080382069 abstract "Background: Peripheral neuropathy is a dose-limiting toxicity of most microtubule-stabilizing chemotherapeutic agents. Ixabepilone, a semisynthetic analog of the natural epothilone B, has activity in a wide range of tumors including taxane-resistant disease. In this study, we sought to understand the effect of ixabepilone on the development of peripheral neuropathy both clinically and its effect at the ultrastructural level of the peripheral nerves and circulating factors over time. Parallel studies in animal models of neuropathy were performed at the same time (Proc AACR 2010 Abstract 4184). Methods: This open-label, non-randomized phase II study enrolled 14 patients with metastatic breast cancer. Ixabepilone was administered by 2 schedules: the FDA approved dose of 40 mg/m 2 every 3 weeks (q3w) and 16 mg/m 2 on day 1, 8, and 15 of a 28-day cycle (weekly). Five controls, 2 with residual taxane-associated peripheral neuropathy and 3 with no prior chemotherapy or peripheral neuropathy, were also accrued. The primary objectives were to characterize the natural history of ixabepilone-associated peripheral neuropathy using the Total Neuropathy Score Clinical (TNSc) assessment tool prior to each cycle and to correlate changes in the ultrastructure of dermal myelinated nerve fibers via a 3 mm punch biopsy of an area 10 cm above the lateral malleolus every 2 cycles with electron microscopy (EM), as well as circulating factors (both inflammatory and neurotrophic) considered to be important in the pathogenesis of chemotherapy-induced peripheral neuropathy. Secondary objectives included progression-free survival (PFS) and non-neurologic toxicity. Results: 14 patients were enrolled and were equally divided between the 2 schedules of ixabepilone chemotherapy. There were no differences in baseline characteristics between the two groups. Mean age was 54 years (range 32–71). Mean number of previous chemotherapy regimens was 3.5 (range 0–8). 57% of patients had received a taxane in the adjuvant setting and 64% in the metastatic setting. The mean neuropathy score (TNSc) at baseline was 4.6 (range 1–11). At a mean cumulative dose of 185 mg/m 2 , the TNSc with ixabepilone q3w schedule was 3.7 points higher/worse (95% CI: 2.2–5.3, p = 0.03) than the mean score observed in patients on the weekly schedule. The sensory component was most significantly affected, predominantly numbness. In 3 patients, the chemotherapy schedule was changed from every 3 weeks to weekly due to > grade 2 toxicity at a mean cumulative dose of 107 mg/m 2 , and TNSc decreased/improved by 2.7 points. PFS in patients on q3w ixabepilone was 133 days (range 28–280) and in patients on weekly ixabepilone was 179 days (range 66–336), nonsignificant. Evaluation of EM and circulating factors is ongoing. Conclusions: Weekly ixabepilone appears to have a more favorable neurotoxicity profile compared to the standard q3w schedule. Integration of the EM data and the circulating factor data are underway and will be presented. Ixabepilone-associated peripheral neuropathy may improve in patients switched to weekly ixabepilone without compromising efficacy. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P1-15-07." @default.
• W2080382069 created "2016-06-24" @default.
• W2080382069 creator A5000761363 @default.
• W2080382069 creator A5004522625 @default.
• W2080382069 creator A5008521807 @default.
• W2080382069 creator A5012671125 @default.
• W2080382069 creator A5028949826 @default.
• W2080382069 creator A5032665185 @default.
• W2080382069 creator A5035918900 @default.
• W2080382069 creator A5042649461 @default.
• W2080382069 creator A5043410493 @default.
• W2080382069 creator A5051231102 @default.
• W2080382069 creator A5061357025 @default.
• W2080382069 creator A5062590037 @default.
• W2080382069 creator A5065426246 @default.
• W2080382069 creator A5067431363 @default.
• W2080382069 creator A5070277835 @default.
• W2080382069 date "2012-12-15" @default.
• W2080382069 modified "2023-09-27" @default.
• W2080382069 title "Abstract P1-15-07: Ixabepilone-associated peripheral neuropathy in metastatic breast cancer patients and its effects on the ultrastructure of neurons" @default.
• W2080382069 doi "https://doi.org/10.1158/0008-5472.sabcs12-p1-15-07" @default.
• W2080382069 hasPublicationYear "2012" @default.
• W2080382069 type Work @default.
• W2080382069 sameAs 2080382069 @default.
• W2080382069 citedByCount "0" @default.
• W2080382069 crossrefType "proceedings-article" @default.
• W2080382069 hasAuthorship W2080382069A5000761363 @default.
• W2080382069 hasAuthorship W2080382069A5004522625 @default.
• W2080382069 hasAuthorship W2080382069A5008521807 @default.
• W2080382069 hasAuthorship W2080382069A5012671125 @default.
• W2080382069 hasAuthorship W2080382069A5028949826 @default.
• W2080382069 hasAuthorship W2080382069A5032665185 @default.
• W2080382069 hasAuthorship W2080382069A5035918900 @default.
• W2080382069 hasAuthorship W2080382069A5042649461 @default.
• W2080382069 hasAuthorship W2080382069A5043410493 @default.
• W2080382069 hasAuthorship W2080382069A5051231102 @default.
• W2080382069 hasAuthorship W2080382069A5061357025 @default.
• W2080382069 hasAuthorship W2080382069A5062590037 @default.
• W2080382069 hasAuthorship W2080382069A5065426246 @default.
• W2080382069 hasAuthorship W2080382069A5067431363 @default.
• W2080382069 hasAuthorship W2080382069A5070277835 @default.
• W2080382069 hasConcept C121608353 @default.
• W2080382069 hasConcept C126322002 @default.
• W2080382069 hasConcept C134018914 @default.
• W2080382069 hasConcept C142724271 @default.
• W2080382069 hasConcept C143998085 @default.
• W2080382069 hasConcept C2775930923 @default.
• W2080382069 hasConcept C2776694085 @default.
• W2080382069 hasConcept C2777511904 @default.
• W2080382069 hasConcept C2779194965 @default.
• W2080382069 hasConcept C2779289229 @default.
• W2080382069 hasConcept C2779901536 @default.
• W2080382069 hasConcept C530470458 @default.
• W2080382069 hasConcept C555293320 @default.
• W2080382069 hasConcept C71924100 @default.
• W2080382069 hasConcept C90924648 @default.
• W2080382069 hasConceptScore W2080382069C121608353 @default.
• W2080382069 hasConceptScore W2080382069C126322002 @default.
• W2080382069 hasConceptScore W2080382069C134018914 @default.
• W2080382069 hasConceptScore W2080382069C142724271 @default.
• W2080382069 hasConceptScore W2080382069C143998085 @default.
• W2080382069 hasConceptScore W2080382069C2775930923 @default.
• W2080382069 hasConceptScore W2080382069C2776694085 @default.
• W2080382069 hasConceptScore W2080382069C2777511904 @default.
• W2080382069 hasConceptScore W2080382069C2779194965 @default.
• W2080382069 hasConceptScore W2080382069C2779289229 @default.
• W2080382069 hasConceptScore W2080382069C2779901536 @default.
• W2080382069 hasConceptScore W2080382069C530470458 @default.
• W2080382069 hasConceptScore W2080382069C555293320 @default.
• W2080382069 hasConceptScore W2080382069C71924100 @default.
• W2080382069 hasConceptScore W2080382069C90924648 @default.
• W2080382069 hasLocation W20803820691 @default.
• W2080382069 hasOpenAccess W2080382069 @default.
• W2080382069 hasPrimaryLocation W20803820691 @default.
• W2080382069 isParatext "false" @default.
• W2080382069 isRetracted "false" @default.
• W2080382069 magId "2080382069" @default.
• W2080382069 workType "article" @default.