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• W2080386965 abstract "In human astrocytoma cell lines, substance P (SP) stimulated interleukin (IL)-8, IL-6, granulocyte macrophage colony-stimulating factor and leukemia inhibitory factor protein secretion. These SP effects were blocked by a specific NK1 tachykinin receptor antagonist. Further, SP stimulation increased the half-life of IL-6 and IL-8 messenger RNAs, suggesting that the synthesis of these cytokines is also regulated post-transcriptionally. SP-induced cytokine release was inhibited by staurosporine and phorbol 12-myristate 13-acetate desensitization suggesting protein kinase C involvement. The demonstration that SP affects cytokine production in glioma cells might be of relevance for the biology of such tumors." @default.
• W2080386965 created "2016-06-24" @default.
• W2080386965 creator A5042601047 @default.
• W2080386965 creator A5059955356 @default.
• W2080386965 date "1998-01-01" @default.
• W2080386965 modified "2023-10-15" @default.
• W2080386965 title "Substance P induces secretion of immunomodulatory cytokines by human astrocytoma cells" @default.
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• W2080386965 doi "https://doi.org/10.1016/s0165-5728(97)00167-7" @default.
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