Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080387290> ?p ?o ?g. }
- W2080387290 endingPage "e216" @default.
- W2080387290 startingPage "e207" @default.
- W2080387290 abstract "On the basis of the Framingham risk algorithm, overestimation of clinical events has been reported in some European populations. Electron-beam computed tomography-derived quantification of coronary artery calcification (CAC) allows for non-invasive assessment of coronary atherosclerosis in the general population and may thus add important in vivo information on the path from risk factor exposure to formation of clinical events. The current study was undertaken to compare the relationship between risk factors and subclinical coronary atherosclerosis between non-Hispanic white cohorts in Germany and US-America, the hypothesis being that subclinical coronary atherosclerosis might be less prevalent in Europe at the same level of classical risk factor exposure.The Heinz Nixdorf Recall (HNR) study, conducted in the German Ruhr area and the Epidemiology of Coronary Calcification (ECAC) study, conducted in Olmsted County, Minnesota, both recruited large unselected cohorts, men and women aged 45-74 years, from the general population. All subjects with no history of coronary artery disease (CAD) or stroke were included (n=3120 in HNR, n=703 in ECAC). Coronary risk factors were assessed by personal and computer-assisted interviews and direct laboratory measurements. Cardiovascular medication use (antihypertensive, lipid-lowering, and anti-diabetic) was noted. CAC scores were determined using the Agatston method in an identical fashion in both studies.Adverse levels of risk factors were more prevalent, and the Framingham risk score was higher (10.6+/-7.6 versus 9.3+/-7.1, p<0.001) in HNR than ECAC, respectively. There was no difference in body mass index (BMI). CAC scores were greater in HNR than in ECAC (mean values, 155.7+/-423.0 versus 107.2+/-280.0; median values, 11.9 versus 2.4; p<0.001, respectively). When subjects were matched on CAD risk factors, presence and quantity of CAC were similar in the 2 cohorts. Risk factors significantly associated with CAC score in both studies included: age, male sex, current and former smoking, systolic blood pressure, and non-HDL-cholesterol. Inferences were similar after excluding subjects using lipid- or blood pressure-lowering medications. Using the same risk factor variables for modelling, the predicted CAC scores were comparable in both cohorts.In the higher-risk German cohort, presence and quantity of CAC were greater than in the lower-risk US-American cohort. Risk factor associations with CAC were very similar in both unselected populations. We could not demonstrate a relative increase in subclinical coronary atherosclerosis in the US-American cohort. It appears possible to compare CAC as a measure of subclinical coronary artery disease in different populations on different continents, and accordingly, scanning guidelines might be translated across these populations." @default.
- W2080387290 created "2016-06-24" @default.
- W2080387290 creator A5001814391 @default.
- W2080387290 creator A5004548589 @default.
- W2080387290 creator A5008211812 @default.
- W2080387290 creator A5008355737 @default.
- W2080387290 creator A5012486943 @default.
- W2080387290 creator A5016859344 @default.
- W2080387290 creator A5043588351 @default.
- W2080387290 creator A5056932952 @default.
- W2080387290 creator A5060048494 @default.
- W2080387290 creator A5064002883 @default.
- W2080387290 creator A5078166854 @default.
- W2080387290 creator A5079426765 @default.
- W2080387290 creator A5080262061 @default.
- W2080387290 creator A5081119135 @default.
- W2080387290 date "2007-11-01" @default.
- W2080387290 modified "2023-10-02" @default.
- W2080387290 title "Comparison of subclinical coronary atherosclerosis and risk factors in unselected populations in Germany and US-America" @default.
- W2080387290 cites W1567231692 @default.
- W2080387290 cites W190232511 @default.
- W2080387290 cites W1966006567 @default.
- W2080387290 cites W1968908907 @default.
- W2080387290 cites W1984722293 @default.
- W2080387290 cites W2010414135 @default.
- W2080387290 cites W2040092628 @default.
- W2080387290 cites W2044788131 @default.
- W2080387290 cites W2058159536 @default.
- W2080387290 cites W2060879025 @default.
- W2080387290 cites W2076846766 @default.
- W2080387290 cites W2082091097 @default.
- W2080387290 cites W2084970194 @default.
- W2080387290 cites W2088551794 @default.
- W2080387290 cites W2108587366 @default.
- W2080387290 cites W2116404316 @default.
- W2080387290 cites W2122576275 @default.
- W2080387290 cites W2137366606 @default.
- W2080387290 cites W2145657805 @default.
- W2080387290 cites W2153785016 @default.
- W2080387290 cites W2153788691 @default.
- W2080387290 cites W2154004228 @default.
- W2080387290 cites W2165884492 @default.
- W2080387290 cites W2315613231 @default.
- W2080387290 cites W2916596946 @default.
- W2080387290 cites W4230870013 @default.
- W2080387290 doi "https://doi.org/10.1016/j.atherosclerosis.2007.04.009" @default.
- W2080387290 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2293130" @default.
- W2080387290 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17532322" @default.
- W2080387290 hasPublicationYear "2007" @default.
- W2080387290 type Work @default.
- W2080387290 sameAs 2080387290 @default.
- W2080387290 citedByCount "53" @default.
- W2080387290 countsByYear W20803872902012 @default.
- W2080387290 countsByYear W20803872902013 @default.
- W2080387290 countsByYear W20803872902014 @default.
- W2080387290 countsByYear W20803872902015 @default.
- W2080387290 countsByYear W20803872902016 @default.
- W2080387290 countsByYear W20803872902017 @default.
- W2080387290 countsByYear W20803872902018 @default.
- W2080387290 countsByYear W20803872902019 @default.
- W2080387290 countsByYear W20803872902020 @default.
- W2080387290 countsByYear W20803872902021 @default.
- W2080387290 countsByYear W20803872902023 @default.
- W2080387290 crossrefType "journal-article" @default.
- W2080387290 hasAuthorship W2080387290A5001814391 @default.
- W2080387290 hasAuthorship W2080387290A5004548589 @default.
- W2080387290 hasAuthorship W2080387290A5008211812 @default.
- W2080387290 hasAuthorship W2080387290A5008355737 @default.
- W2080387290 hasAuthorship W2080387290A5012486943 @default.
- W2080387290 hasAuthorship W2080387290A5016859344 @default.
- W2080387290 hasAuthorship W2080387290A5043588351 @default.
- W2080387290 hasAuthorship W2080387290A5056932952 @default.
- W2080387290 hasAuthorship W2080387290A5060048494 @default.
- W2080387290 hasAuthorship W2080387290A5064002883 @default.
- W2080387290 hasAuthorship W2080387290A5078166854 @default.
- W2080387290 hasAuthorship W2080387290A5079426765 @default.
- W2080387290 hasAuthorship W2080387290A5080262061 @default.
- W2080387290 hasAuthorship W2080387290A5081119135 @default.
- W2080387290 hasBestOaLocation W20803872902 @default.
- W2080387290 hasConcept C107130276 @default.
- W2080387290 hasConcept C113280763 @default.
- W2080387290 hasConcept C11783203 @default.
- W2080387290 hasConcept C126322002 @default.
- W2080387290 hasConcept C164705383 @default.
- W2080387290 hasConcept C2778213512 @default.
- W2080387290 hasConcept C2779134260 @default.
- W2080387290 hasConcept C2780221984 @default.
- W2080387290 hasConcept C2780586474 @default.
- W2080387290 hasConcept C2780609585 @default.
- W2080387290 hasConcept C2908647359 @default.
- W2080387290 hasConcept C2991716557 @default.
- W2080387290 hasConcept C2994533308 @default.
- W2080387290 hasConcept C50440223 @default.
- W2080387290 hasConcept C71924100 @default.
- W2080387290 hasConcept C99454951 @default.
- W2080387290 hasConceptScore W2080387290C107130276 @default.
- W2080387290 hasConceptScore W2080387290C113280763 @default.
- W2080387290 hasConceptScore W2080387290C11783203 @default.