FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080394041> ?p ?o ?g. }

• W2080394041 endingPage "38" @default.
• W2080394041 startingPage "30" @default.
• W2080394041 abstract "Hydrogen peroxide is the co-substrate used by the enzyme catalase to form Compound I (the catalase-H2O2 system), which is the major pathway for the conversion of ethanol (EtOH) into acetaldehyde in the brain. This acetaldehyde has been involved in many of the effects of EtOH. Previous research demonstrated that treatments that change the levels of cerebral H2O2 available to catalase modulate the locomotor-stimulating effects of EtOH and its volitional intake in rodents. However, the source of H2O2 which is used by catalase to form Compound I and mediates the psychoactive actions of EtOH is unknown. One cause of the generation of H2O2 in the brain comes from the deamination of biogenic amines by the activity of MAO-A. Here we explore the consequences of the administration of the MAO-A inhibitor clorgyline on EtOH-induced locomotion and voluntary EtOH drinking. For the locomotor activity tests, we injected Swiss (RjOrl) mice intraperitoneally (IP) with clorgyline (0-10mg/kg) and later (0.5-8h) with EtOH (0-3.75 g/kg; IP). Following these treatments, mice were placed in locomotor activity chambers to measure their locomotion. For the drinking experiments, mice of the C57BL/6J strain were injected IP with clorgyline prior to offering them an EtOH (20%) solution following a drinking-in-the-dark procedure. Additional experiments were performed to assess the selectivity of this compound in altering EtOH-stimulated locomotion and EtOH intake. Moreover, we indirectly tested the ability of clorgyline to reduce brain H2O2 levels. We showed that this treatment selectively reduced EtOH-induced locomotion and its self-administration. Moreover, this compound decreased central H2O2 levels available to catalase. We suggest that H2O2 derived from the deamination of biogenic amines by the activity of MAO-A could determine the formation of brain EtOH-derived acetaldehyde. This centrally-formed acetaldehyde within the neurons of the aminergic system could play a role in the neurobehavioral properties of EtOH." @default.
• W2080394041 created "2016-06-24" @default.
• W2080394041 creator A5007751436 @default.
• W2080394041 creator A5011910797 @default.
• W2080394041 creator A5012309404 @default.
• W2080394041 creator A5021106532 @default.
• W2080394041 date "2014-01-01" @default.
• W2080394041 modified "2023-10-17" @default.
• W2080394041 title "The MAO-A inhibitor clorgyline reduces ethanol-induced locomotion and its volitional intake in mice" @default.
• W2080394041 cites W151349690 @default.
• W2080394041 cites W1518223360 @default.
• W2080394041 cites W1524008440 @default.
• W2080394041 cites W1790419435 @default.
• W2080394041 cites W1816365875 @default.
• W2080394041 cites W1874199142 @default.
• W2080394041 cites W1891973497 @default.
• W2080394041 cites W1895595836 @default.
• W2080394041 cites W1963494069 @default.
• W2080394041 cites W1963825128 @default.
• W2080394041 cites W1969903780 @default.
• W2080394041 cites W1970756197 @default.
• W2080394041 cites W1970796549 @default.
• W2080394041 cites W1975875405 @default.
• W2080394041 cites W1977289860 @default.
• W2080394041 cites W1982235280 @default.
• W2080394041 cites W1983012384 @default.
• W2080394041 cites W1983240333 @default.
• W2080394041 cites W1984608961 @default.
• W2080394041 cites W1985159618 @default.
• W2080394041 cites W1987511810 @default.
• W2080394041 cites W1988586625 @default.
• W2080394041 cites W1990319677 @default.
• W2080394041 cites W1990724312 @default.
• W2080394041 cites W1992004606 @default.
• W2080394041 cites W1992746782 @default.
• W2080394041 cites W1993146643 @default.
• W2080394041 cites W1994557023 @default.
• W2080394041 cites W1994970739 @default.
• W2080394041 cites W1998054220 @default.
• W2080394041 cites W1999284447 @default.
• W2080394041 cites W2002472871 @default.
• W2080394041 cites W2007270827 @default.
• W2080394041 cites W2007321017 @default.
• W2080394041 cites W2008478633 @default.
• W2080394041 cites W2011506772 @default.
• W2080394041 cites W2011795123 @default.
• W2080394041 cites W2012587742 @default.
• W2080394041 cites W2015426800 @default.
• W2080394041 cites W2016038628 @default.
• W2080394041 cites W2016771892 @default.
• W2080394041 cites W2016975502 @default.
• W2080394041 cites W2018242239 @default.
• W2080394041 cites W2018785988 @default.
• W2080394041 cites W2022626753 @default.
• W2080394041 cites W2023545889 @default.
• W2080394041 cites W2024258467 @default.
• W2080394041 cites W2025065453 @default.
• W2080394041 cites W2027053646 @default.
• W2080394041 cites W2029294505 @default.
• W2080394041 cites W2029383300 @default.
• W2080394041 cites W2032437333 @default.
• W2080394041 cites W2033604860 @default.
• W2080394041 cites W2036751844 @default.
• W2080394041 cites W2037513755 @default.
• W2080394041 cites W2043502874 @default.
• W2080394041 cites W2045584885 @default.
• W2080394041 cites W2046911557 @default.
• W2080394041 cites W2048610185 @default.
• W2080394041 cites W2052362668 @default.
• W2080394041 cites W2052450737 @default.
• W2080394041 cites W2052560618 @default.
• W2080394041 cites W2054532827 @default.
• W2080394041 cites W2054663416 @default.
• W2080394041 cites W2054702858 @default.
• W2080394041 cites W2055380784 @default.
• W2080394041 cites W2057104160 @default.
• W2080394041 cites W2057644086 @default.
• W2080394041 cites W2066081053 @default.
• W2080394041 cites W2070349559 @default.
• W2080394041 cites W2074320107 @default.
• W2080394041 cites W2077435495 @default.
• W2080394041 cites W2078100908 @default.
• W2080394041 cites W2084981345 @default.
• W2080394041 cites W2085251599 @default.
• W2080394041 cites W2087288531 @default.
• W2080394041 cites W2092609164 @default.
• W2080394041 cites W2093172763 @default.
• W2080394041 cites W2094540217 @default.
• W2080394041 cites W2114045252 @default.
• W2080394041 cites W2124041135 @default.
• W2080394041 cites W2128840417 @default.
• W2080394041 cites W2129318408 @default.
• W2080394041 cites W2151438998 @default.
• W2080394041 cites W2157427399 @default.
• W2080394041 cites W2163042508 @default.
• W2080394041 cites W2163814494 @default.
• W2080394041 cites W2258375165 @default.
• W2080394041 cites W4237575636 @default.

• next