FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080396341> ?p ?o ?g. }

• W2080396341 endingPage "987" @default.
• W2080396341 startingPage "976" @default.
• W2080396341 abstract "The outer membrane lipoprotein, P6 of Haemophilus influenzae was studied to determine the importance of the native palmitoyl moiety on its physicochemical and immunological properties. A recombinant P6 (rP6) molecule devoid of lipidation signal sequence was expressed in Escherichia coli and its properties were compared to those of the palmitylated protein purified from H. influenzae. The isoelectric point of rP6 was more acidic than that of the native protein and also exhibited less secondary structure than P6 as judged by circular dichroism. However, both forms of P6 induced identical P6-specific antibody titers in guinea pigs when Freund's adjuvant was used. These antisera reacted with a panel of overlapping P6 peptides in a comparable manner and in addition, rabbit antisera raised against the P6 peptides reacted equally well with P6 and rP6. Furthermore, all human convalescent sera tested exhibited similar anti-P6 and anti-rP6 antibody titers. However, rP6 was less immunogenic than P6 when administered either without adjuvant or in alum and when tested in competitive inhibition studies with anti-P6 antibodies, was a less effective inhibitor than native P6, suggesting a diminution in some of the antigenic activity of rP6. In spite of these differences, rP6 was capable of eliciting a protective antibody response against live H. influenzae type b challenge in a modified infant rat model of bacteremia. These findings demonstrate that the non-fatty acylated rP6 could possibily be substituted for native P6 in a vaccine against H. influenzae." @default.
• W2080396341 created "2016-06-24" @default.
• W2080396341 creator A5000607023 @default.
• W2080396341 creator A5006191599 @default.
• W2080396341 creator A5012817686 @default.
• W2080396341 creator A5033040498 @default.
• W2080396341 creator A5047401432 @default.
• W2080396341 creator A5061325723 @default.
• W2080396341 creator A5062456441 @default.
• W2080396341 creator A5086640891 @default.
• W2080396341 creator A5089890097 @default.
• W2080396341 date "1997-06-01" @default.
• W2080396341 modified "2023-09-25" @default.
• W2080396341 title "Effect of lipid modification on the physicochemical, structural, antigenic and immunoprotective properties of Haemophilus influenzae outer membrane protein P6" @default.
• W2080396341 cites W1506565605 @default.
• W2080396341 cites W1575745715 @default.
• W2080396341 cites W1577069249 @default.
• W2080396341 cites W1593177179 @default.
• W2080396341 cites W1782814620 @default.
• W2080396341 cites W1864840202 @default.
• W2080396341 cites W1894476426 @default.
• W2080396341 cites W1926738805 @default.
• W2080396341 cites W1931984331 @default.
• W2080396341 cites W1937456523 @default.
• W2080396341 cites W1938211295 @default.
• W2080396341 cites W1955467646 @default.
• W2080396341 cites W1968740719 @default.
• W2080396341 cites W1975085160 @default.
• W2080396341 cites W1984512389 @default.
• W2080396341 cites W1984777363 @default.
• W2080396341 cites W1984795798 @default.
• W2080396341 cites W1994396808 @default.
• W2080396341 cites W2021501853 @default.
• W2080396341 cites W2027297527 @default.
• W2080396341 cites W2066861122 @default.
• W2080396341 cites W2072931485 @default.
• W2080396341 cites W2074817232 @default.
• W2080396341 cites W2085002427 @default.
• W2080396341 cites W2094352852 @default.
• W2080396341 cites W2097033383 @default.
• W2080396341 cites W2100837269 @default.
• W2080396341 cites W2107938087 @default.
• W2080396341 cites W2108715124 @default.
• W2080396341 cites W2109692249 @default.
• W2080396341 cites W2112488741 @default.
• W2080396341 cites W2115298547 @default.
• W2080396341 cites W2116128404 @default.
• W2080396341 cites W2126108250 @default.
• W2080396341 cites W2126719129 @default.
• W2080396341 cites W2131691351 @default.
• W2080396341 cites W2155894308 @default.
• W2080396341 cites W2160788969 @default.
• W2080396341 cites W2271527765 @default.
• W2080396341 cites W2323185543 @default.
• W2080396341 cites W4233893970 @default.
• W2080396341 cites W4296380130 @default.
• W2080396341 doi "https://doi.org/10.1016/s0264-410x(96)00296-4" @default.
• W2080396341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9261944" @default.
• W2080396341 hasPublicationYear "1997" @default.
• W2080396341 type Work @default.
• W2080396341 sameAs 2080396341 @default.
• W2080396341 citedByCount "21" @default.
• W2080396341 countsByYear W20803963412013 @default.
• W2080396341 countsByYear W20803963412020 @default.
• W2080396341 countsByYear W20803963412023 @default.
• W2080396341 crossrefType "journal-article" @default.
• W2080396341 hasAuthorship W2080396341A5000607023 @default.
• W2080396341 hasAuthorship W2080396341A5006191599 @default.
• W2080396341 hasAuthorship W2080396341A5012817686 @default.
• W2080396341 hasAuthorship W2080396341A5033040498 @default.
• W2080396341 hasAuthorship W2080396341A5047401432 @default.
• W2080396341 hasAuthorship W2080396341A5061325723 @default.
• W2080396341 hasAuthorship W2080396341A5062456441 @default.
• W2080396341 hasAuthorship W2080396341A5086640891 @default.
• W2080396341 hasAuthorship W2080396341A5089890097 @default.
• W2080396341 hasConcept C104317684 @default.
• W2080396341 hasConcept C144464004 @default.
• W2080396341 hasConcept C146587185 @default.
• W2080396341 hasConcept C147483822 @default.
• W2080396341 hasConcept C159654299 @default.
• W2080396341 hasConcept C185592680 @default.
• W2080396341 hasConcept C203014093 @default.
• W2080396341 hasConcept C2776925733 @default.
• W2080396341 hasConcept C2777863537 @default.
• W2080396341 hasConcept C2780868878 @default.
• W2080396341 hasConcept C501593827 @default.
• W2080396341 hasConcept C523546767 @default.
• W2080396341 hasConcept C54355233 @default.
• W2080396341 hasConcept C547475151 @default.
• W2080396341 hasConcept C55493867 @default.
• W2080396341 hasConcept C86803240 @default.
• W2080396341 hasConcept C89423630 @default.
• W2080396341 hasConcept C91523082 @default.
• W2080396341 hasConceptScore W2080396341C104317684 @default.
• W2080396341 hasConceptScore W2080396341C144464004 @default.
• W2080396341 hasConceptScore W2080396341C146587185 @default.
• W2080396341 hasConceptScore W2080396341C147483822 @default.
• W2080396341 hasConceptScore W2080396341C159654299 @default.

• next