FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080401908> ?p ?o ?g. }

• W2080401908 endingPage "1197" @default.
• W2080401908 startingPage "1185" @default.
• W2080401908 abstract "We report the engineering and characterization of paraoxonase-3 knockout mice (Pon3KO). The mice were generally healthy but exhibited quantitative alterations in bile acid metabolism and a 37% increased body weight compared to the wild-type mice on a high fat diet. PON3 was enriched in the mitochondria-associated membrane fraction of hepatocytes. PON3 deficiency resulted in impaired mitochondrial respiration, increased mitochondrial superoxide levels, and increased hepatic expression of inflammatory genes. PON3 deficiency did not influence atherosclerosis development on an apolipoprotein E null hyperlipidemic background, but it did lead to a significant 60% increase in atherosclerotic lesion size in Pon3KO mice on the C57BL/6J background when fed a cholate-cholesterol diet. On the diet, the Pon3KO had significantly increased plasma intermediate-density lipoprotein/LDL cholesterol and bile acid levels. They also exhibited significantly elevated levels of hepatotoxicity markers in circulation, a 58% increase in gallstone weight, a 40% increase in hepatic cholesterol level, and increased mortality. Furthermore, Pon3KO mice exhibited decreased hepatic bile acid synthesis and decreased bile acid levels in the small intestine compared with wild-type mice. Our study suggests a role for PON3 in the metabolism of lipid and bile acid as well as protection against atherosclerosis, gallstone disease, and obesity.—Shih, D. M., Yu, J. M., Vergnes, L., Dali-Youcef, N., Champion, M. D., Devarajan, A., Zhang, P., Castellani, L. W., Brindley, D. N., Jamey, C. Auwerx, J., Reddy, S. T., Ford, D. A., Reue, K., Lusis, A. J. PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis. FASEB J. 29, 1185-1197 (2015). www.fasebj.org" @default.
• W2080401908 created "2016-06-24" @default.
• W2080401908 creator A5000693838 @default.
• W2080401908 creator A5003154600 @default.
• W2080401908 creator A5006865443 @default.
• W2080401908 creator A5011375089 @default.
• W2080401908 creator A5019216998 @default.
• W2080401908 creator A5019944871 @default.
• W2080401908 creator A5021649597 @default.
• W2080401908 creator A5024741961 @default.
• W2080401908 creator A5039852816 @default.
• W2080401908 creator A5041550820 @default.
• W2080401908 creator A5042735174 @default.
• W2080401908 creator A5046386333 @default.
• W2080401908 creator A5056009731 @default.
• W2080401908 creator A5056419667 @default.
• W2080401908 creator A5079909478 @default.
• W2080401908 date "2014-12-04" @default.
• W2080401908 modified "2023-10-11" @default.
• W2080401908 title "PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis" @default.
• W2080401908 cites W1561328546 @default.
• W2080401908 cites W1671050155 @default.
• W2080401908 cites W1774964093 @default.
• W2080401908 cites W1824181430 @default.
• W2080401908 cites W1901163999 @default.
• W2080401908 cites W1966922165 @default.
• W2080401908 cites W1967324781 @default.
• W2080401908 cites W1980829529 @default.
• W2080401908 cites W1984044242 @default.
• W2080401908 cites W1989314123 @default.
• W2080401908 cites W1990051093 @default.
• W2080401908 cites W1991638587 @default.
• W2080401908 cites W1997307574 @default.
• W2080401908 cites W1997544016 @default.
• W2080401908 cites W1997660418 @default.
• W2080401908 cites W1998927777 @default.
• W2080401908 cites W2008378566 @default.
• W2080401908 cites W2010381644 @default.
• W2080401908 cites W2018422556 @default.
• W2080401908 cites W2026537091 @default.
• W2080401908 cites W2037197890 @default.
• W2080401908 cites W2040901772 @default.
• W2080401908 cites W2051054763 @default.
• W2080401908 cites W2055083588 @default.
• W2080401908 cites W2057059633 @default.
• W2080401908 cites W2064929307 @default.
• W2080401908 cites W2067696474 @default.
• W2080401908 cites W2067790100 @default.
• W2080401908 cites W2068992647 @default.
• W2080401908 cites W2069633173 @default.
• W2080401908 cites W2072433515 @default.
• W2080401908 cites W2074151167 @default.
• W2080401908 cites W2074327708 @default.
• W2080401908 cites W2074798171 @default.
• W2080401908 cites W2078503590 @default.
• W2080401908 cites W2078810890 @default.
• W2080401908 cites W2082315075 @default.
• W2080401908 cites W2094999489 @default.
• W2080401908 cites W2095395771 @default.
• W2080401908 cites W2096321546 @default.
• W2080401908 cites W2096664466 @default.
• W2080401908 cites W2099040294 @default.
• W2080401908 cites W2105586683 @default.
• W2080401908 cites W2106069121 @default.
• W2080401908 cites W2107378767 @default.
• W2080401908 cites W2108475283 @default.
• W2080401908 cites W2122341467 @default.
• W2080401908 cites W2122432643 @default.
• W2080401908 cites W2128817061 @default.
• W2080401908 cites W2134897177 @default.
• W2080401908 cites W2140059081 @default.
• W2080401908 cites W2146735845 @default.
• W2080401908 cites W2152311269 @default.
• W2080401908 cites W2154168373 @default.
• W2080401908 cites W2156593520 @default.
• W2080401908 cites W2165144161 @default.
• W2080401908 cites W2167519336 @default.
• W2080401908 cites W2168115093 @default.
• W2080401908 cites W2168526937 @default.
• W2080401908 cites W2169044648 @default.
• W2080401908 cites W2169664803 @default.
• W2080401908 cites W2171308395 @default.
• W2080401908 cites W2300552860 @default.
• W2080401908 cites W288924213 @default.
• W2080401908 cites W41193317 @default.
• W2080401908 cites W2062056936 @default.
• W2080401908 doi "https://doi.org/10.1096/fj.14-260570" @default.
• W2080401908 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4396607" @default.
• W2080401908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25477283" @default.
• W2080401908 hasPublicationYear "2014" @default.
• W2080401908 type Work @default.
• W2080401908 sameAs 2080401908 @default.
• W2080401908 citedByCount "32" @default.
• W2080401908 countsByYear W20804019082016 @default.
• W2080401908 countsByYear W20804019082017 @default.
• W2080401908 countsByYear W20804019082018 @default.
• W2080401908 countsByYear W20804019082019 @default.
• W2080401908 countsByYear W20804019082020 @default.

• next