FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080403150> ?p ?o ?g. }

• W2080403150 endingPage "1179" @default.
• W2080403150 startingPage "1172" @default.
• W2080403150 abstract "Summary Aortic valve stenosis (AS) shares several similarities with atherosclerosis. Factor XIII (FXIII) has been detected within atherosclerotic plaques and may contribute to the development of atherosclerosis via multiple mechanisms. In the current study, we sought to investigate FXIII expression within human stenotic aortic valves and its association with severity of the disease. We prospectively enrolled 91 consecutive patients with AS scheduled for isolated valve replacement. Valvular FXIII subunit A (FXIII-A), fibrin and macrophages expression was evaluated by immunostaining. FXIII-A subunit transcripts and FXIII-A Val34Leu polymorphism was determined by real-time PCR. Plasma FXIII (pFXIII) activity was measured. We demonstrated that the valvular FXIII-A was predominantly expressed on the aortic side of leaflets, colocalized with alternatively activated macrophages (AAM). Areas stained for FXIII-A showed positive correlations with valvular fibrin presence, degree of calcification, pFXIII activity and the severity of AS, reflected by mean and maximum transvalvular gradients (all, p<0.001). The FXIII-A mRNA in the stenotic leaflets was significantly elevated compared to control leaflets. Interestingly, pFXIII activity was also positively correlated with mean (p<0.001) and maximum (p=0.001) transvalvular gradient. The FXIII-A Val34Leu polymorphism did not affect FXIII-A and fibrin expression in AS valves. In conclusion, the study is the first to show abundant expression of FXIII-A at the mRNA and protein levels within human stenotic aortic valves, which is associated with the severity of AS. Our findings might suggest that FXIII in the stenotic valves is presented in AAM and may be involved in the AS progression." @default.
• W2080403150 created "2016-06-24" @default.
• W2080403150 creator A5002139502 @default.
• W2080403150 creator A5028119329 @default.
• W2080403150 creator A5047128739 @default.
• W2080403150 creator A5047958060 @default.
• W2080403150 creator A5059598724 @default.
• W2080403150 creator A5072453639 @default.
• W2080403150 creator A5089364840 @default.
• W2080403150 date "2012-01-01" @default.
• W2080403150 modified "2023-09-27" @default.
• W2080403150 title "Factor XIII expression within aortic valves and its plasma activity in patients with aortic stenosis: association with severity of disease" @default.
• W2080403150 cites W1963515616 @default.
• W2080403150 cites W1983142129 @default.
• W2080403150 cites W1983220630 @default.
• W2080403150 cites W1986813540 @default.
• W2080403150 cites W1995656674 @default.
• W2080403150 cites W2000359966 @default.
• W2080403150 cites W2022359228 @default.
• W2080403150 cites W2036894466 @default.
• W2080403150 cites W2037586865 @default.
• W2080403150 cites W2063962827 @default.
• W2080403150 cites W2065181902 @default.
• W2080403150 cites W2074947849 @default.
• W2080403150 cites W2090061871 @default.
• W2080403150 cites W2093014406 @default.
• W2080403150 cites W2096931418 @default.
• W2080403150 cites W2099782020 @default.
• W2080403150 cites W2103509293 @default.
• W2080403150 cites W2113836385 @default.
• W2080403150 cites W2128887897 @default.
• W2080403150 cites W2146788236 @default.
• W2080403150 cites W2151796223 @default.
• W2080403150 cites W2152723000 @default.
• W2080403150 cites W2155399624 @default.
• W2080403150 cites W2158282429 @default.
• W2080403150 cites W2164138396 @default.
• W2080403150 cites W2170126665 @default.
• W2080403150 cites W2184661661 @default.
• W2080403150 cites W2311906414 @default.
• W2080403150 cites W4324113932 @default.
• W2080403150 cites W46031774 @default.
• W2080403150 cites W77183089 @default.
• W2080403150 doi "https://doi.org/10.1160/th12-07-0455" @default.
• W2080403150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23052999" @default.
• W2080403150 hasPublicationYear "2012" @default.
• W2080403150 type Work @default.
• W2080403150 sameAs 2080403150 @default.
• W2080403150 citedByCount "18" @default.
• W2080403150 countsByYear W20804031502012 @default.
• W2080403150 countsByYear W20804031502013 @default.
• W2080403150 countsByYear W20804031502014 @default.
• W2080403150 countsByYear W20804031502015 @default.
• W2080403150 countsByYear W20804031502016 @default.
• W2080403150 countsByYear W20804031502019 @default.
• W2080403150 countsByYear W20804031502020 @default.
• W2080403150 countsByYear W20804031502021 @default.
• W2080403150 countsByYear W20804031502022 @default.
• W2080403150 countsByYear W20804031502023 @default.
• W2080403150 crossrefType "journal-article" @default.
• W2080403150 hasAuthorship W2080403150A5002139502 @default.
• W2080403150 hasAuthorship W2080403150A5028119329 @default.
• W2080403150 hasAuthorship W2080403150A5047128739 @default.
• W2080403150 hasAuthorship W2080403150A5047958060 @default.
• W2080403150 hasAuthorship W2080403150A5059598724 @default.
• W2080403150 hasAuthorship W2080403150A5072453639 @default.
• W2080403150 hasAuthorship W2080403150A5089364840 @default.
• W2080403150 hasConcept C126322002 @default.
• W2080403150 hasConcept C164705383 @default.
• W2080403150 hasConcept C203014093 @default.
• W2080403150 hasConcept C2779672106 @default.
• W2080403150 hasConcept C2779980429 @default.
• W2080403150 hasConcept C2780007028 @default.
• W2080403150 hasConcept C2780714102 @default.
• W2080403150 hasConcept C2781414266 @default.
• W2080403150 hasConcept C54173615 @default.
• W2080403150 hasConcept C71924100 @default.
• W2080403150 hasConceptScore W2080403150C126322002 @default.
• W2080403150 hasConceptScore W2080403150C164705383 @default.
• W2080403150 hasConceptScore W2080403150C203014093 @default.
• W2080403150 hasConceptScore W2080403150C2779672106 @default.
• W2080403150 hasConceptScore W2080403150C2779980429 @default.
• W2080403150 hasConceptScore W2080403150C2780007028 @default.
• W2080403150 hasConceptScore W2080403150C2780714102 @default.
• W2080403150 hasConceptScore W2080403150C2781414266 @default.
• W2080403150 hasConceptScore W2080403150C54173615 @default.
• W2080403150 hasConceptScore W2080403150C71924100 @default.
• W2080403150 hasIssue "12" @default.
• W2080403150 hasLocation W20804031501 @default.
• W2080403150 hasLocation W20804031502 @default.
• W2080403150 hasOpenAccess W2080403150 @default.
• W2080403150 hasPrimaryLocation W20804031501 @default.
• W2080403150 hasRelatedWork W1983749074 @default.
• W2080403150 hasRelatedWork W2014714330 @default.
• W2080403150 hasRelatedWork W2029376091 @default.
• W2080403150 hasRelatedWork W2062431605 @default.
• W2080403150 hasRelatedWork W2071188398 @default.
• W2080403150 hasRelatedWork W2079459316 @default.

• next