FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080403703> ?p ?o ?g. }

• W2080403703 endingPage "304" @default.
• W2080403703 startingPage "291" @default.
• W2080403703 abstract "The basic helix–loop–helix DNA binding protein Hand2 has critical functions in cardiac development both in neural crest-derived and mesoderm-derived structures. Targeted deletion of Hand2 in the neural crest has allowed us to genetically dissect Hand2-dependent defects specifically in outflow tract and cardiac cushion independent of Hand2 functions in mesoderm-derived structures. Targeted deletion of Hand2 in the neural crest results in misalignment of the aortic arch arteries and outflow tract, contributing to development of double outlet right ventricle (DORV) and ventricular septal defects (VSD). These neural crest-derived developmental anomalies are associated with altered expression of Hand2-target genes we have identified by gene profiling. A number of Hand2 direct target genes have been identified using ChIP and ChIP-on-chip analyses. We have identified and validated a number of genes related to cell migration, proliferation/cell cycle and intracellular signaling whose expression is affected by Hand2 deletion in the neural crest and which are associated with development of VSD and DORV. Our data suggest that Hand2 is a multifunctional DNA binding protein affecting expression of target genes associated with a number of functional interactions in neural crest-derived cells required for proper patterning of the outflow tract, generation of the appropriate number of neural crest-derived cells for elongation of the conotruncus and cardiac cushion organization. Our genetic model has made it possible to investigate the molecular genetics of neural crest contributions to outflow tract morphogenesis and cell differentiation." @default.
• W2080403703 created "2016-06-24" @default.
• W2080403703 creator A5006213316 @default.
• W2080403703 creator A5016471668 @default.
• W2080403703 creator A5036888371 @default.
• W2080403703 creator A5042551963 @default.
• W2080403703 creator A5064373792 @default.
• W2080403703 creator A5076954824 @default.
• W2080403703 date "2010-05-01" @default.
• W2080403703 modified "2023-10-14" @default.
• W2080403703 title "Targeted deletion of Hand2 in cardiac neural crest-derived cells influences cardiac gene expression and outflow tract development" @default.
• W2080403703 cites W1509578353 @default.
• W2080403703 cites W1535291574 @default.
• W2080403703 cites W1561598641 @default.
• W2080403703 cites W1606727311 @default.
• W2080403703 cites W1608875353 @default.
• W2080403703 cites W1824991881 @default.
• W2080403703 cites W1857978595 @default.
• W2080403703 cites W1937613866 @default.
• W2080403703 cites W1939326986 @default.
• W2080403703 cites W1964226556 @default.
• W2080403703 cites W1964480889 @default.
• W2080403703 cites W1965936283 @default.
• W2080403703 cites W1970172422 @default.
• W2080403703 cites W1970804331 @default.
• W2080403703 cites W1971764800 @default.
• W2080403703 cites W1973431915 @default.
• W2080403703 cites W1973749378 @default.
• W2080403703 cites W1976691820 @default.
• W2080403703 cites W1977926834 @default.
• W2080403703 cites W1979185250 @default.
• W2080403703 cites W1979784727 @default.
• W2080403703 cites W1981210511 @default.
• W2080403703 cites W1982296490 @default.
• W2080403703 cites W1983804435 @default.
• W2080403703 cites W1984798293 @default.
• W2080403703 cites W1987499371 @default.
• W2080403703 cites W1987624648 @default.
• W2080403703 cites W1988173672 @default.
• W2080403703 cites W1990078733 @default.
• W2080403703 cites W1990112482 @default.
• W2080403703 cites W1991472810 @default.
• W2080403703 cites W1993477468 @default.
• W2080403703 cites W1993913999 @default.
• W2080403703 cites W1993994530 @default.
• W2080403703 cites W1994142299 @default.
• W2080403703 cites W1994323615 @default.
• W2080403703 cites W1995946981 @default.
• W2080403703 cites W1997415972 @default.
• W2080403703 cites W1997426465 @default.
• W2080403703 cites W2000865482 @default.
• W2080403703 cites W2002597733 @default.
• W2080403703 cites W2003426511 @default.
• W2080403703 cites W2003461650 @default.
• W2080403703 cites W2007116888 @default.
• W2080403703 cites W2008241074 @default.
• W2080403703 cites W2010010140 @default.
• W2080403703 cites W2011237068 @default.
• W2080403703 cites W2012125908 @default.
• W2080403703 cites W2012927070 @default.
• W2080403703 cites W2014001268 @default.
• W2080403703 cites W2015747269 @default.
• W2080403703 cites W2017458728 @default.
• W2080403703 cites W2018824203 @default.
• W2080403703 cites W2019007505 @default.
• W2080403703 cites W2020312446 @default.
• W2080403703 cites W2023061467 @default.
• W2080403703 cites W2023542247 @default.
• W2080403703 cites W2024192698 @default.
• W2080403703 cites W2025091389 @default.
• W2080403703 cites W2029157857 @default.
• W2080403703 cites W2029773366 @default.
• W2080403703 cites W2031323365 @default.
• W2080403703 cites W2034454142 @default.
• W2080403703 cites W2035288932 @default.
• W2080403703 cites W2038510434 @default.
• W2080403703 cites W2039922719 @default.
• W2080403703 cites W2040427118 @default.
• W2080403703 cites W2044287935 @default.
• W2080403703 cites W2050004680 @default.
• W2080403703 cites W2051947374 @default.
• W2080403703 cites W2053797631 @default.
• W2080403703 cites W2053940114 @default.
• W2080403703 cites W2055191807 @default.
• W2080403703 cites W2055853433 @default.
• W2080403703 cites W2058704011 @default.
• W2080403703 cites W2060313378 @default.
• W2080403703 cites W2062548336 @default.
• W2080403703 cites W2064912523 @default.
• W2080403703 cites W2068852923 @default.
• W2080403703 cites W2069123665 @default.
• W2080403703 cites W2070279485 @default.
• W2080403703 cites W2070444361 @default.
• W2080403703 cites W2072989962 @default.
• W2080403703 cites W2073615403 @default.
• W2080403703 cites W207413701 @default.
• W2080403703 cites W2074493585 @default.
• W2080403703 cites W2075152619 @default.

• next