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- W2080403967 endingPage "197" @default.
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- W2080403967 abstract "Cellular responses to environmental or physiological cues rely on transduction pathways that must ensure discrimination between different signals. These cascades 'crosstalk' and lead to a combinatorial regulation. This often results in different combinations of post-translational modifications (PTMs) on target proteins, which might act as a molecular barcode. Although appealing, the idea of the existence of such a code for transcription factors is debated. Using general arguments and recent evidence, we propose that a PTM code is not only possible but necessary in the context of transcription factors regulating multiple processes. Thus, the coding potential of PTM combinations should both provide a further layer of information integration from several transduction pathways and warrant highly specific cellular outputs." @default.
- W2080403967 created "2016-06-24" @default.
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- W2080403967 date "2009-05-01" @default.
- W2080403967 modified "2023-10-10" @default.
- W2080403967 title "A post-translational modification code for transcription factors: sorting through a sea of signals" @default.
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- W2080403967 doi "https://doi.org/10.1016/j.tcb.2009.02.003" @default.
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