FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080404930> ?p ?o ?g. }

• W2080404930 endingPage "441" @default.
• W2080404930 startingPage "435" @default.
• W2080404930 abstract "Thiopurine S-methyltransferase (TPMT) is an enzyme that catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine, 6-thioguanine, and azathioprine. TPMT activity exhibits an interindividual variability, mainly as a result of genetic polymorphism. Patients with intermediate or deficient TMPT activity are at risk for toxicity after receiving standard doses of thiopurine drugs. It has previously been reported that 3 variant alleles: TPMT*2, *3A, and *3C are responsible for over 95% cases of low enzyme activity. The purpose of this study was to explore the association between these polymorphisms and the occurrence of azathioprine adverse effects in 112 renal transplant recipients undergoing triple immunosuppressive therapy including azathioprine, cyclosporine, and prednisone. TPMT genetic polymorphism was determined using PCR-RFLP and allele-specific PCR methods. Azathioprine dose, leukocyte, erythrocyte, and platelet counts, graft rejection episodes, as well as cyclosporine levels were analyzed throughout the first year after organ transplantation. We found the frequency of leukopenia episodes (WBC < 4.0 × 109/L) significantly higher in heterozygous patients (53.8%) compared with those with TPMT wild-type genotype (23.5%). One patient, who was a compound homozygote (3A/*3C), experienced severe azathioprine-related myelotoxicity each time after receiving the standard drug dose. Our results suggest that polymorphisms in TPMT gene may be responsible for approximately 12.5% of all leukopenia episodes in renal transplant recipients treated with azathioprine. Genotyping for the major TPMT variant alleles may be a valuable tool in preventing AZA toxicity and optimization of immunosuppressive therapy." @default.
• W2080404930 created "2016-06-24" @default.
• W2080404930 creator A5009502694 @default.
• W2080404930 creator A5026513321 @default.
• W2080404930 creator A5038074828 @default.
• W2080404930 creator A5040660360 @default.
• W2080404930 creator A5078060252 @default.
• W2080404930 date "2005-08-01" @default.
• W2080404930 modified "2023-10-18" @default.
• W2080404930 title "The Impact of Thiopurine S-Methyltransferase Polymorphism on Azathioprine-Induced Myelotoxicity in Renal Transplant Recipients" @default.
• W2080404930 cites W1252407659 @default.
• W2080404930 cites W1969556302 @default.
• W2080404930 cites W1973499262 @default.
• W2080404930 cites W1984169395 @default.
• W2080404930 cites W1986278569 @default.
• W2080404930 cites W1996409190 @default.
• W2080404930 cites W1999416574 @default.
• W2080404930 cites W2014389034 @default.
• W2080404930 cites W2017060960 @default.
• W2080404930 cites W2019378963 @default.
• W2080404930 cites W2022893236 @default.
• W2080404930 cites W2027183498 @default.
• W2080404930 cites W2031824679 @default.
• W2080404930 cites W2033674020 @default.
• W2080404930 cites W2034809256 @default.
• W2080404930 cites W2073747924 @default.
• W2080404930 cites W2076472107 @default.
• W2080404930 cites W2084271415 @default.
• W2080404930 cites W2086196338 @default.
• W2080404930 cites W2091516505 @default.
• W2080404930 cites W2113649985 @default.
• W2080404930 cites W2116765834 @default.
• W2080404930 cites W2126845363 @default.
• W2080404930 cites W2133841376 @default.
• W2080404930 cites W2139458933 @default.
• W2080404930 cites W2145720060 @default.
• W2080404930 cites W2156950528 @default.
• W2080404930 cites W2271765448 @default.
• W2080404930 cites W4256135490 @default.
• W2080404930 doi "https://doi.org/10.1097/01.ftd.0000164393.09402.c9" @default.
• W2080404930 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16044099" @default.
• W2080404930 hasPublicationYear "2005" @default.
• W2080404930 type Work @default.
• W2080404930 sameAs 2080404930 @default.
• W2080404930 citedByCount "44" @default.
• W2080404930 countsByYear W20804049302013 @default.
• W2080404930 countsByYear W20804049302014 @default.
• W2080404930 countsByYear W20804049302015 @default.
• W2080404930 countsByYear W20804049302016 @default.
• W2080404930 countsByYear W20804049302017 @default.
• W2080404930 countsByYear W20804049302018 @default.
• W2080404930 countsByYear W20804049302019 @default.
• W2080404930 countsByYear W20804049302021 @default.
• W2080404930 countsByYear W20804049302023 @default.
• W2080404930 crossrefType "journal-article" @default.
• W2080404930 hasAuthorship W2080404930A5009502694 @default.
• W2080404930 hasAuthorship W2080404930A5026513321 @default.
• W2080404930 hasAuthorship W2080404930A5038074828 @default.
• W2080404930 hasAuthorship W2080404930A5040660360 @default.
• W2080404930 hasAuthorship W2080404930A5078060252 @default.
• W2080404930 hasConcept C104317684 @default.
• W2080404930 hasConcept C126322002 @default.
• W2080404930 hasConcept C135763542 @default.
• W2080404930 hasConcept C197934379 @default.
• W2080404930 hasConcept C203014093 @default.
• W2080404930 hasConcept C2776760755 @default.
• W2080404930 hasConcept C2778330430 @default.
• W2080404930 hasConcept C2779134260 @default.
• W2080404930 hasConcept C2780303639 @default.
• W2080404930 hasConcept C2780873365 @default.
• W2080404930 hasConcept C2911091166 @default.
• W2080404930 hasConcept C29730261 @default.
• W2080404930 hasConcept C54355233 @default.
• W2080404930 hasConcept C55775858 @default.
• W2080404930 hasConcept C70917649 @default.
• W2080404930 hasConcept C71924100 @default.
• W2080404930 hasConcept C86803240 @default.
• W2080404930 hasConcept C90924648 @default.
• W2080404930 hasConcept C98274493 @default.
• W2080404930 hasConceptScore W2080404930C104317684 @default.
• W2080404930 hasConceptScore W2080404930C126322002 @default.
• W2080404930 hasConceptScore W2080404930C135763542 @default.
• W2080404930 hasConceptScore W2080404930C197934379 @default.
• W2080404930 hasConceptScore W2080404930C203014093 @default.
• W2080404930 hasConceptScore W2080404930C2776760755 @default.
• W2080404930 hasConceptScore W2080404930C2778330430 @default.
• W2080404930 hasConceptScore W2080404930C2779134260 @default.
• W2080404930 hasConceptScore W2080404930C2780303639 @default.
• W2080404930 hasConceptScore W2080404930C2780873365 @default.
• W2080404930 hasConceptScore W2080404930C2911091166 @default.
• W2080404930 hasConceptScore W2080404930C29730261 @default.
• W2080404930 hasConceptScore W2080404930C54355233 @default.
• W2080404930 hasConceptScore W2080404930C55775858 @default.
• W2080404930 hasConceptScore W2080404930C70917649 @default.
• W2080404930 hasConceptScore W2080404930C71924100 @default.
• W2080404930 hasConceptScore W2080404930C86803240 @default.
• W2080404930 hasConceptScore W2080404930C90924648 @default.
• W2080404930 hasConceptScore W2080404930C98274493 @default.

• next