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• W2080405692 abstract "L’expression multi-tissulaire du récepteur de l’érythropoïétine (Epo-R) confère à celle-ci différentes activités qui viennent s’ajouter à celle de régulation de la production des globules rouges. Cette revue se focalise sur les fonctions de l’érythropoïétine (Epo) au cours du développement du cerveau ainsi que sur ses effets dans la neuroprotection. L’Epo-R est exprimée par différents types cellulaires dans le cerveau tels que les progéniteurs de cellules neurales (NPC), les astrocytes, les neurones, les oligodendrocytes. L’Epo est produite par les cellules résidentes du cerveau sous condition hypoxique et permet ainsi la prolifération des NPC et leur différentiation. Une atteinte du développement du cerveau avec des lésions cérébrales est observée chez des souris dont les gènes de l’Epo et de son récepteur sont manquants. Dans des modèles animaux expérimentaux d’hypoxie-ischémie (HI) ou d’attaque cérébrale, l’injection d’Epo réduit la taille de la lésion ainsi que les dommages. D’un point de vue clinique, les effets thérapeutiques de l’Epo semblent prometteurs mais demandent de plus amples investigations. Erythropoietin (Epo) has long been recognised for its role in the control of erythropoiesis and therefore in the treatment of anemia including anemia of prematurity. The erythropoietin receptor (Epo-R) though is expressed in many other organs including the CNS. This review focuses on the role of erythropoietin during the development of the CNS and its potential role as a neuroprotective agent. Epo-R is expressed in many different cellules of the CNS during development including neural progenitor cells, neurons, astrocytes and oligodendrocytes. In the event of hypoxia CNS cells respond with increase of erythropoietin release with subsequent stimulation of neurogenesis through Epo-R on neural progenitor cells. In an Epo-R knock-out model therefore cerebral development is severely impaired. In models of hypoxia-ischemia exogenous Epo has been shown to reduce lesion size and improve structural and functional recovery. Human studies are emerging using Epo as a neuroprotective agent both for the term infant with hypoxiaischemia as well as for the extremely preterm infant." @default.
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• W2080405692 date "2010-09-01" @default.
• W2080405692 modified "2023-10-18" @default.
• W2080405692 title "Érythropoïétine et neuroprotection" @default.
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• W2080405692 doi "https://doi.org/10.1016/s0929-693x(10)70905-2" @default.
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