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- W2080409616 abstract "THE WEIGHT OF EVIDENCE in man and in several species of animals, including the dog, indicates that the major portion of orally administered vitamin B<sub>12</sub>is absorbed from the distal ileum.<sup>1-4</sup>Other investigators, however, have variously indicated that the maximal absorption of vitamin B<sub>12</sub>takes place in the duodenum,<sup>5</sup>in the jejunum,<sup>6</sup>or throughout the entire small intestine.<sup>7</sup> Studies also indicate that a substance from gastric mucosa, probably a mucopolysaccharide termed intrinsic factor, forms a complex with vitamin B<sub>12</sub>, thereby enhancing its absorption by the intestine. It has been suggested that a possible explanation for the conflicting evidence as to the site of absorption of vitamin B<sub>12</sub>may be the inconstant availability of endogenous intrinsic factor during transit from stomach to ileum. This might result from the binding of vitamin B<sub>12</sub>by proteins without intrinsic factor activity, making it unavailable" @default.
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- W2080409616 date "1963-05-04" @default.
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- W2080409616 title "Role of the Ileum in the Absorption of Vitamin B12 and Intrinsic Factor (NF)" @default.
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- W2080409616 doi "https://doi.org/10.1001/jama.1963.73700180001009" @default.
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