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• W2080415871 endingPage "245" @default.
• W2080415871 startingPage "237" @default.
• W2080415871 abstract "Standard anti-leishmanial drugs were tested for their ability to inhibit the growth of intracellular amastigotes of Leishmania aethiopica, L. donovani and L. infantum in the human leukemia monocyte THP-1 cell line. Sodium stibogluconate and meglumine antimoniate were active against L. donovani with ED50 values of 8.9 μg Sbv/ml and 2.9 μg Sbv/ml, respectively. L. aethiopica was less sensitive to sodium stibogluconate with an ED50 value of 25.3 μg Sbv/ml while pentamidine had an ED50 value of 0.6 μM. Both L. donovani (ED50, 9.3 μM), and L. aethiopica (ED50, 6.4 μM), were sensitive to aminosidine sulphate. An L. infantum isolate, clinically resistant to meglumine antimoniate treatment, had an ED50 of 22.2 μg Sbv/ml. The toxic level of drugs on host cells was determined by colorimetric Methyl Tetrazolium (MTT) assay prior to activity tests. The results obtained with the THP-1 in vitro drug screening model were similar to those obtained in the mouse peritoneal macrophage model." @default.
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• W2080415871 date "1992-08-01" @default.
• W2080415871 modified "2023-09-23" @default.
• W2080415871 title "An in vitro model for screening antileishmanial drugs: the human leukaemia monocyte cell line, THP-1" @default.
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• W2080415871 doi "https://doi.org/10.1016/0001-706x(92)90042-v" @default.
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