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- W2080416664 abstract "2,6-Di-terf-butyl-8-hydroxy-dibenzofuran-l,4-quinone (BHDQ) is one of the oxidative derivatives of butylated hydroxyanisole. The suppressive effect of BHDQ on the mutagenicity of Trp-P-2 was investigated using Salmonella typhimurium ΤΑ 98. BHDQ (0.8 nmol) suppressed the mutagenicity of Trp-P-2 (0.2 nmol) by 30 % in the presence of the S9 mix. The suppressive activity of BHDQ toward the mutagenicity of the activated metabolite of Trp-P-2, N-OH-Trp-P-2, in the absence of the S9 mix was 80 %. The bio-antimutagenicity of BHDQ was also measured, but it was found to be negligible as compared to its desmutagenicity. The reaction of BHDQ with N-OH-Trp-P-2 re-produced Trp-P-2. It was considered that BHDQ should re-convert N-OH-Trp-P-2 to the original Trp-P-2, and therefore BHDQ should be a desmutagen." @default.
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- W2080416664 date "1989-01-01" @default.
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- W2080416664 title "Desmutagenicity of a dibenzofuran-quinone derivative toward the mutagenicity of Trp-P-2." @default.
- W2080416664 doi "https://doi.org/10.1271/bbb1961.53.959" @default.
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