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- W2080421188 abstract "Abstract Kumar, S., Ahmad, A.H. and Sharma.L.D. 1999. Pharmacokinetics of sulfamethoxypyridazine following intravenous administration in renal impaired goats. J. Appl. Anim. Res., 16: 147–152. Pharmacokinetics of sulfamethoxypyridazine (SMPZ) was studied following intravenous dose (25mg/kg) in normal and renal impaired goats. Therapeutic concentration (25/*micro;g/ml) in plasma was maintained upto 4 and 18h in normal and renal impaired goats, respectively. The plasma elimination half life was 29h, 36 min in renal impaired goats compared to 6h, 5min in normal ones. The volume of distribution was similar in both normal and renal impaired goats. Clearance of SMPZ was significantly (p<0.01) lower in renal impaired goats (0.25ml/min/kg) compared to normal ones (lml/min/kg). Area under the curve was significantly (P<0.01) higher in renal impaired (100196μg/ml.min) compared to normal goats (24876μ/ml.min). Based on the pharmacokinetic parameters intravenous dosage regimen in renal impaired goats (priming dose of..." @default.
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- W2080421188 date "1999-12-01" @default.
- W2080421188 modified "2023-09-23" @default.
- W2080421188 title "Pharmacokinetics of Sulfamethoxypyridazine Following Intravenous Administration in Renal Impaired Goats" @default.
- W2080421188 cites W2079221235 @default.
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- W2080421188 doi "https://doi.org/10.1080/09712119.1999.9706275" @default.
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