Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080425802> ?p ?o ?g. }
- W2080425802 endingPage "14" @default.
- W2080425802 startingPage "1" @default.
- W2080425802 abstract "Lens arises from ectoderm situated next to the optic vesicles. By thickening and invaginating, the ectoderm forms the lens vesicle. Growth factors are key regulators of cell fate and behavior. Current evidence indicates that FGFs and BMPs are required to induce lens differentiation from ectoderm. In the lens vesicle, posterior cells elongate to form the primary fibers whereas anterior cells differentiate into epithelial cells. The divergent fates of these embryonic cells give the lens its distinctive polarity. There is now compelling evidence that, at least in mammals, FGF is required to initiate fiber differentiation and that progression of this complex process depends on the synchronized and integrated action of a number of distinct growth factor-induced signaling pathways. It is also proposed that an antero-posterior gradient of FGF stimulation in the mammalian eye ensures that the lens attains and maintains its polarity and growth patterns. Less is known about differentiation of the lens epithelium; however, recent studies point to a role for Wnt signaling. Multiple Wnts and their receptors are expressed in the lens epithelium, and mice with impaired Wnt signaling have a deficient epithelium. Recent studies also indicate that other families of molecules, that can modulate growth factor signaling, have a role in regulating the ordered growth and differentiation of the lens." @default.
- W2080425802 created "2016-06-24" @default.
- W2080425802 creator A5010409541 @default.
- W2080425802 creator A5033120393 @default.
- W2080425802 date "2005-04-01" @default.
- W2080425802 modified "2023-10-12" @default.
- W2080425802 title "Growth factor regulation of lens development" @default.
- W2080425802 cites W1494862987 @default.
- W2080425802 cites W1530337671 @default.
- W2080425802 cites W1540618004 @default.
- W2080425802 cites W1547704219 @default.
- W2080425802 cites W1557960509 @default.
- W2080425802 cites W1584556634 @default.
- W2080425802 cites W165253497 @default.
- W2080425802 cites W1789601839 @default.
- W2080425802 cites W1917414630 @default.
- W2080425802 cites W1925182101 @default.
- W2080425802 cites W1948282121 @default.
- W2080425802 cites W1964927712 @default.
- W2080425802 cites W1965284493 @default.
- W2080425802 cites W1966015382 @default.
- W2080425802 cites W1966248136 @default.
- W2080425802 cites W1972014445 @default.
- W2080425802 cites W1972255735 @default.
- W2080425802 cites W1972850991 @default.
- W2080425802 cites W1978908452 @default.
- W2080425802 cites W1979925752 @default.
- W2080425802 cites W1982266611 @default.
- W2080425802 cites W1982586017 @default.
- W2080425802 cites W1982589114 @default.
- W2080425802 cites W1986095782 @default.
- W2080425802 cites W1986456038 @default.
- W2080425802 cites W1991714681 @default.
- W2080425802 cites W1993606572 @default.
- W2080425802 cites W1994488178 @default.
- W2080425802 cites W1995380186 @default.
- W2080425802 cites W1995787154 @default.
- W2080425802 cites W1997277166 @default.
- W2080425802 cites W1998082957 @default.
- W2080425802 cites W2006253263 @default.
- W2080425802 cites W2008169769 @default.
- W2080425802 cites W2010532737 @default.
- W2080425802 cites W2011666168 @default.
- W2080425802 cites W2012348124 @default.
- W2080425802 cites W2014409793 @default.
- W2080425802 cites W2016359709 @default.
- W2080425802 cites W2017269815 @default.
- W2080425802 cites W2019886971 @default.
- W2080425802 cites W2024451865 @default.
- W2080425802 cites W2024967780 @default.
- W2080425802 cites W2028453954 @default.
- W2080425802 cites W2029317481 @default.
- W2080425802 cites W2029763409 @default.
- W2080425802 cites W2030382396 @default.
- W2080425802 cites W2035184168 @default.
- W2080425802 cites W2036724511 @default.
- W2080425802 cites W2037876473 @default.
- W2080425802 cites W2038144063 @default.
- W2080425802 cites W2039571997 @default.
- W2080425802 cites W2040472376 @default.
- W2080425802 cites W2042822047 @default.
- W2080425802 cites W2043784713 @default.
- W2080425802 cites W2044764655 @default.
- W2080425802 cites W2046386833 @default.
- W2080425802 cites W2050248396 @default.
- W2080425802 cites W2055097300 @default.
- W2080425802 cites W2055524055 @default.
- W2080425802 cites W2055808176 @default.
- W2080425802 cites W2055992647 @default.
- W2080425802 cites W2057639102 @default.
- W2080425802 cites W2058528119 @default.
- W2080425802 cites W2058743622 @default.
- W2080425802 cites W2061067706 @default.
- W2080425802 cites W2062519756 @default.
- W2080425802 cites W2063034492 @default.
- W2080425802 cites W2063765502 @default.
- W2080425802 cites W2064526228 @default.
- W2080425802 cites W2064855528 @default.
- W2080425802 cites W2065963604 @default.
- W2080425802 cites W2066300943 @default.
- W2080425802 cites W2069022895 @default.
- W2080425802 cites W2071957913 @default.
- W2080425802 cites W2072071819 @default.
- W2080425802 cites W2072182205 @default.
- W2080425802 cites W2073294657 @default.
- W2080425802 cites W2073305486 @default.
- W2080425802 cites W2073339066 @default.
- W2080425802 cites W2074371171 @default.
- W2080425802 cites W2074626858 @default.
- W2080425802 cites W2077549378 @default.
- W2080425802 cites W2079673523 @default.
- W2080425802 cites W2081072827 @default.
- W2080425802 cites W2082676215 @default.
- W2080425802 cites W2083387492 @default.
- W2080425802 cites W2089407911 @default.
- W2080425802 cites W2092508299 @default.
- W2080425802 cites W2094417543 @default.
- W2080425802 cites W2097090948 @default.