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- W2080432557 abstract "Spinal cord injury (SCI) induces retrograde cell death in descending pathways, which can be prevented by long-term intrathecal infusion of neurotrophins (Novikova et al. [2000] Eur J Neurosci 12:776-780). The present study investigates whether the same treatment also leads to improved regeneration of the injured tracts. After cervical SCI in adult rats, a peripheral nerve graft was attached to the rostral wall of the lesion cavity. The animals were treated by local application into the cavity of Gelfoam soaked in (1) phosphate buffered saline (untreated controls) or (2) a mixture of the neurotrophins brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) (local treatment), or by intrathecal infusion of BDNF + NT-3 for (3) 2 weeks (short-term treatment) or (4) 5-8 weeks (long-term treatment). Despite a very strong survival effect, long-term treatment failed to stimulate ingrowth of descending tracts into the nerve graft. In comparison with untreated controls, the latter treatment also caused 35% reduction in axonal sprouting of descending pathways rostral to the lesion site and 72% reduction in the number of spinal cord neurons extending axons into the nerve graft. Local and short-term treatments neither prevented retrograde cell death nor enhanced regeneration of descending tracts, but induced robust regeneration of spinal cord neurons into the nerve graft. These results indicate that the signal pathways promoting neuronal survival and axonal regeneration, respectively, in descending tracts after SCI respond differently to neurotrophic stimuli and that efficient rescue of axotomized tract neurons is not a sufficient prerequisite for regeneration." @default.
- W2080432557 created "2016-06-24" @default.
- W2080432557 creator A5023432530 @default.
- W2080432557 creator A5028310930 @default.
- W2080432557 creator A5030364668 @default.
- W2080432557 date "2002-09-25" @default.
- W2080432557 modified "2023-10-02" @default.
- W2080432557 title "Differential effects of neurotrophins on neuronal survival and axonal regeneration after spinal cord injury in adult rats" @default.
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- W2080432557 doi "https://doi.org/10.1002/cne.10381" @default.
- W2080432557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12353221" @default.
- W2080432557 hasPublicationYear "2002" @default.
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