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- W2080432816 abstract "Tight regulation of the cell cycle and DNA repair machinery is essential for maintaining genome stability. The APC/CCdh1 ubiquitin ligase complex is a key regulator of protein stability during the G1 phase of the cell cycle. APC/CCdh1 regulates and promotes the degradation of proteins involved in both cell cycle regulation and DNA repair. In a recent study, we identified a novel APC/CCdh1 substrate, the ubiquitin protease USP1. USP1 is a critical regulator of both the Fanconi anemia (FA) and translesion synthesis (TLS) DNA repair pathways. Here, we provide additional mechanistic insights into the regulation of USP1 during the cell cycle. Specifically, we demonstrate that USP1 is phosphorylated in mitosis by cyclin-dependent kinases (Cdks), and that this phosphorylation event may prevent premature degradation of USP1 during normal cell cycle progression. Finally, we provide a unifying hypothesis integrating the role of G1-specific proteolysis of USP1 with the regulation of the transcriptional repressors, Inhibitor of DNA-binding (ID) proteins." @default.
- W2080432816 created "2016-06-24" @default.
- W2080432816 creator A5022580770 @default.
- W2080432816 creator A5070809614 @default.
- W2080432816 creator A5074359093 @default.
- W2080432816 date "2011-12-01" @default.
- W2080432816 modified "2023-09-27" @default.
- W2080432816 title "Insights into phosphorylation-dependent mechanisms regulating USP1 protein stability during the cell cycle" @default.
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- W2080432816 doi "https://doi.org/10.4161/cc.10.23.18501" @default.
- W2080432816 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3272283" @default.
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- W2080432816 hasPublicationYear "2011" @default.
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