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• W2080433494 endingPage "e1003854" @default.
• W2080433494 startingPage "e1003854" @default.
• W2080433494 abstract "Pure populations of quiescent yeast can be obtained from stationary phase cultures that have ceased proliferation after exhausting glucose and other carbon sources from their environment. They are uniformly arrested in the G1 phase of the cell cycle, and display very high thermo-tolerance and longevity. We find that G1 arrest is initiated before all the glucose has been scavenged from the media. Maintaining G1 arrest requires transcriptional repression of the G1 cyclin, CLN3, by Xbp1. Xbp1 is induced as glucose is depleted and it is among the most abundant transcripts in quiescent cells. Xbp1 binds and represses CLN3 transcription and in the absence of Xbp1, or with extra copies of CLN3, cells undergo ectopic divisions and produce very small cells. The Rad53-mediated replication stress checkpoint reinforces the arrest and becomes essential when Cln3 is overproduced. The XBP1 transcript also undergoes metabolic oscillations under glucose limitation and we identified many additional transcripts that oscillate out of phase with XBP1 and have Xbp1 binding sites in their promoters. Further global analysis revealed that Xbp1 represses 15% of all yeast genes as they enter the quiescent state and over 500 of these transcripts contain Xbp1 binding sites in their promoters. Xbp1-repressed transcripts are highly enriched for genes involved in the regulation of cell growth, cell division and metabolism. Failure to repress some or all of these targets leads xbp1 cells to enter a permanent arrest or senescence with a shortened lifespan." @default.
• W2080433494 created "2016-06-24" @default.
• W2080433494 creator A5003459424 @default.
• W2080433494 creator A5019534392 @default.
• W2080433494 creator A5054850777 @default.
• W2080433494 creator A5060020867 @default.
• W2080433494 date "2013-10-31" @default.
• W2080433494 modified "2023-10-17" @default.
• W2080433494 title "Xbp1 Directs Global Repression of Budding Yeast Transcription during the Transition to Quiescence and Is Important for the Longevity and Reversibility of the Quiescent State" @default.
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• W2080433494 doi "https://doi.org/10.1371/journal.pgen.1003854" @default.
• W2080433494 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3814307" @default.
• W2080433494 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24204289" @default.
• W2080433494 hasPublicationYear "2013" @default.
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