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• W2080446747 abstract "Radiotracers labelled with short-lived fluorine-18 (t1/2 = 109.7 min) are keenly sought for biomedical imaging with positron emission tomography (PET). The radiotracers are mostly required at high specific radioactivities, necessitating their radiosyntheses from cyclotron-produced no-carrier-added [18F]fluoride ion. PET radiotracers encompass wide structural diversity and molecular weight. Hence, diverse 18F-labeling methodology is needed to accomplish the required radiosyntheses in a simple and rapid manner. A useful strategy is to introduce nucleophilic [18F]fluoride ion first into a labeling synthon that may then be applied to label the target radiotracer. Here, we show that various functionalized [18F]fluoroarenes may be rapidly synthesized as labeling synthons through single-step reactions of appropriate diaryliodonium salts with [18F]fluoride ion. Decay-corrected radiochemical yields (RCYs) varied with position of functional group, choice of electron-rich aryl ring in the diaryliodonium salt, and choice of anion. Under best conditions, 18F-labeled fluorobenzaldehydes, fluorobenzyl halides, fluorobenzoic acid esters and fluorophenyl ketones were obtained selectively in 40–73%, 20–55%, 46–89% and 81–98% RCYs, respectively. This versatile straightforward methodology will enhance the scope for producing structurally complex, yet useful, PET radiotracers." @default.
• W2080446747 created "2016-06-24" @default.
• W2080446747 creator A5041599982 @default.
• W2080446747 creator A5048937067 @default.
• W2080446747 date "2013-01-01" @default.
• W2080446747 modified "2023-10-07" @default.
• W2080446747 title "Single-step syntheses of no-carrier-added functionalized [18F]fluoroarenes as labeling synthons from diaryliodonium salts" @default.
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• W2080446747 doi "https://doi.org/10.1039/c3ob41353e" @default.
• W2080446747 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4184149" @default.
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• W2080446747 hasPublicationYear "2013" @default.
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