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• W2080449905 abstract "Multistep microwave-assisted reactions toward the synthesis of hydantoin-fused tricyclic tetrahydro-β-carbolines on the soluble polymer support have been developed. Polymer-bound tryptophan with various aldehydes has been subjected to Pictet–Spengler reaction to obtain tricyclic β-carboline conjugates. The terminal hydantoinyl moiety is constructed across polymer-bound β-carbolines by the reaction with various isocyanates under microwave irradiation to form urea intermediate. Simultaneous intramolecular cyclization of urea followed by cleavage of the polymer support leads to a traceless synthesis of tetracyclic scaffolds in high yield and high purity." @default.
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• W2080449905 date "2007-11-01" @default.
• W2080449905 modified "2023-09-23" @default.
• W2080449905 title "Microwave-assisted traceless synthesis of hydantion-fused β-carboline scaffold" @default.
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• W2080449905 doi "https://doi.org/10.1016/j.tet.2007.09.054" @default.
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